NLRP6 Polyclonal Antibody | MyBioSource MBS2519919 product information

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company name :

MyBioSource

product type :

antibody

product name :

NLRP6 Polyclonal Antibody

catalog :

MBS2519919

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using NLRP6 Polyclonal Antibody at dilution 1:40

image 2 :

Immunohistochemistry of paraffin-embedded Human brain tissue using NLRP6 Polyclonal Antibody at dilution 1:40

product information

catalog number :

MBS2519919

products type :

Antibody

products full name :

NLRP6 Polyclonal Antibody

products short name :

[NLRP6]

products name syn :

[AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR]

other names :

[NACHT, LRR and PYD domains-containing protein 6 isoform 2; NACHT, LRR and PYD domains-containing protein 6; NACHT, LRR and PYD domains-containing protein 6; NACHT, LRR and PYD containing protein 6; NACHT, leucine rich repeat and PYD containing 6; PYRIN-containing APAF1-like protein 5; angiotensin II/vasopressin receptor; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; NLR family, pyrin domain containing 6; Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5]

products gene name :

[NLRP6]

other gene names :

[NLRP6; NLRP6; AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR; NALP6; PYPAF5]

uniprot entry name :

NALP6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

purity :

Affinity purification

concentration :

0.6mg/mL

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:50-1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human NLRP6

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products categories :

Cell biology

products description :

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

452085173

ncbi acc num :

NP_612202

ncbi gb acc num :

NM_001276700.1

uniprot acc num :

P59044

ncbi mol weight :

98,681 Da

ncbi summary :

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

uniprot summary :

NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family. Protein type: Receptor, misc. Chromosomal Location of Human Ortholog: 11p15. Cellular Component: nuclear membrane; cytoplasm; plasma membrane. Molecular Function: ATP binding; vasopressin receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; response to bacterium; wound healing; negative regulation of MAPKKK cascade; regulation of inflammatory response; negative regulation of immune response; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; negative regulation of I-kappaB kinase/NF-kappaB cascade

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage