MMP1 Polyclonal Antibody | MyBioSource MBS2519111 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MMP1 Polyclonal Antibody

catalog :

MBS2519111

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of PC3 cell and Mouse muscle tissue, A375 cell using MMP1 Polyclonal Antibody at dilution of 1:500

image 2 :

Immunohistochemistry of paraffin-embedded Human liver cancer using MMP1 Polyclonal Antibody at dilution of 1:60

image 3 :

Immunohistochemistry of paraffin-embedded Human lung cancer using MMP1 Polyclonal Antibody at dilution of 1:60

product information

catalog number :

MBS2519111

products type :

Antibody

products full name :

MMP1 Polyclonal Antibody

products short name :

[MMP1]

products name syn :

[CLG; CLGN]

other names :

[MMP1 protein, partial; Interstitial collagenase; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1; matrix metallopeptidase 1 (interstitial collagenase); Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1]

products gene name :

[MMP1]

other gene names :

[MMP1; MMP1; CLG; CLGN; CLG; MMP-1]

uniprot entry name :

MMP1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

232

purity :

Affinity purification

form :

PBS with 0.05% sodium azide, 50% glycerol, pH 7.3

concentration :

2.2mg/mL

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:200-1:1000. IHC: 1:50-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

products categories :

Cancer; Cell biology; Epigenetics

products description :

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

ncbi gi num :

15341877

ncbi acc num :

AAH13118.1

uniprot acc num :

BC013875

ncbi mol weight :

54,007 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Basigin Interactions Pathway (106065); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Cell Surface Interactions At The Vascular Wall Pathway (106062); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Endothelins Pathway (137958); Extracellular Matrix Organization Pathway (576262); Glucocorticoid Receptor Regulatory Network Pathway (138014)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

uniprot summary :

MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat s mediated neurotoxicity. Belongs to the peptidase M10A family. Protein type: Secreted, signal peptide; EC 3.4.24.7; Motility/polarity/chemotaxis; Secreted; Protease. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: proteinaceous extracellular matrix; extracellular region. Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding. Biological Process: collagen catabolic process; extracellular matrix disassembly; positive regulation of protein oligomerization; extracellular matrix organization and biogenesis; cellular protein metabolic process; viral reproduction; proteolysis; blood coagulation; leukocyte migration. Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage