RAD51 Polyclonal Antibody | MyBioSource MBS2518708 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAD51 Polyclonal Antibody

catalog :

MBS2518708

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using RAD51 Polyclonal Antibody at dilution 1:30

image 2 :

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using RAD51 Polyclonal Antibody at dilution 1:30

product information

catalog number :

MBS2518708

products type :

Antibody

products full name :

RAD51 Polyclonal Antibody

products short name :

[RAD51]

products name syn :

[RECA, BRCC5, MRMV2, HRAD51, RAD51A, HsRad51, HsT16930]

other names :

[RAD51; DNA repair protein RAD51 homolog 1; DNA repair protein RAD51 homolog 1; BRCA1/BRCA2-containing complex, subunit 5; RAD51 homolog A; RecA, E. coli, homolog of; RecA-like protein; recombination protein A; RAD51 recombinase; RAD51 homolog A]

products gene name :

[RAD51]

other gene names :

[RAD51; RAD51; RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930; RAD51A; RECA; HsRAD51; hRAD51]

uniprot entry name :

RAD51_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

339

purity :

Affinity purification

concentration :

0.3mg/mL

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human RAD51

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products description :

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

49168602

ncbi acc num :

NP_597994

uniprot acc num :

Q06609

ncbi pathways :

Assembly Of The RAD51-ssDNA Nucleoprotein Complex Pathway (105873); BARD1 Signaling Events Pathway (137959); Cell Cycle Pathway (530733); DNA Repair Pathway (105837); DNA Damage Response Pathway (198788); Double-Strand Break Repair Pathway (105861); Fanconi Anemia Pathway (377262); Fanconi Anemia Pathway (377128); Homologous DNA Pairing And Strand Exchange Pathway (105870); Homologous Recombination Repair Pathway (105862)

ncbi summary :

uniprot summary :

RAD51: a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported. Protein type: DNA repair, damage; Mitochondrial. Chromosomal Location of Human Ortholog: 15q15.1. Cellular Component: nucleoplasm; nuclear chromosome; lateral element; PML body; condensed nuclear chromosome; mitochondrion; perinuclear region of cytoplasm; mitochondrial matrix; cytoplasm; nucleolus; microtubule organizing center; condensed chromosome; nucleus. Molecular Function: protein C-terminus binding; identical protein binding; protein binding; double-stranded DNA binding; damaged DNA binding; single-stranded DNA-dependent ATPase activity; single-stranded DNA binding; ATP binding. Biological Process: DNA unwinding during replication; meiosis; DNA recombinase assembly; mitotic recombination; meiotic recombination; double-strand break repair; positive regulation of DNA ligation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination; protein homooligomerization; DNA recombination. Disease: Breast Cancer; Mirror Movements 2

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage