catalog number :
MBS251819
products type :
Recombinant Protein
products full name :
Neuregulin 2 (NRG2)
products short name :
Neuregulin 2 (NRG2)
other names :
neuregulin 2 isoform 2; Pro-neuregulin-2, membrane-bound isoform; pro-neuregulin-2, membrane-bound isoform; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; neuregulin 2; Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases; NTAK
products gene name :
NRG2
other gene names :
NRG2; NRG2; DON1; HRG2; NTAK; NTAK; Pro-NRG2; NRG-2; DON-1; NTAK
uniprot entry name :
NRG2_HUMAN
sequence :
MGHHHHHHSGSEF-FSMLLFGVSL ACYSPSLKSV QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI SVGSCVPLER NQRYIFFLEP TEQPLVFKTA F
other info1 :
Tag Information: N-terminal His-Tag
other info2 :
Organism: Homo sapiens (Human)
ncbi acc num :
AAF28849.1
ncbi mol weight :
70,637 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764!!Downregulation Of ERBB2:ERBB3 Signaling Pathway 530740!!Downstream Signal Transduction Pathway 106385!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250!!Downstream Signaling Of Activated FGFR Pathway 160957!!ErbB Receptor Signaling Network Pathway 138016
ncbi summary :
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]