product summary
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company name :
MyBioSource
product type :
antibody
product name :
PPIA Polyclonal Antibody
catalog :
MBS2518180
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS2518180 image 1
Western Blot analysis of Hela, hepg2 and PC3 cell using PPIA Polyclonal Antibody at dilution of 1:300
product information
catalog number :
MBS2518180
products type :
Antibody
products full name :
PPIA Polyclonal Antibody
products short name :
[PPIA]
products name syn :
[CYPA; CYPH; HEL-S-69p]
other names :
[PPIA; Peptidyl-prolyl cis-trans isomerase A; peptidyl-prolyl cis-trans isomerase A; PPIase A; T cell cyclophilin; cyclosporin A-binding protein; epididymis secretory sperm binding protein Li 69p; rotamase A; peptidylprolyl isomerase A (cyclophilin A); Cyclophilin A; Cyclosporin A-binding protein; Rotamase APeptidyl-prolyl cis-trans isomerase A, N-terminally processed]
products gene name :
[PPIA]
other gene names :
[PPIA; PPIA; CYPA; CYPH; HEL-S-69p; CYPA; PPIase A]
uniprot entry name :
PPIA_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
165
purity :
Affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:200-1:1000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human PPIA. Calculated Molecular Weight: 18kDa
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products description :
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
ncbi gi num :
48145531
ncbi acc num :
BC000689
uniprot acc num :
P62937
ncbi pathways :
APOBEC3G Mediated Resistance To HIV-1 Infection Pathway (106016); Assembly Of The HIV Virion Pathway (106008); Basigin Interactions Pathway (106065); Binding And Entry Of HIV Virion Pathway (105986); Budding And Maturation Of HIV Virion Pathway (106009); Cell Surface Interactions At The Vascular Wall Pathway (106062); Disease Pathway (530764); Early Phase Of HIV Life Cycle Pathway (105985); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984)
ncbi summary :
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
uniprot summary :
PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. Protein type: RNA-binding; EC 5.2.1.8; Isomerase; Cyclophilin. Chromosomal Location of Human Ortholog: 7p13. Cellular Component: extracellular space; focal adhesion; membrane; extracellular region; nucleus; cytosol. Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; virion binding; peptide binding. Biological Process: release of virus from host; platelet activation; uncoating of virus; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; protein folding; viral reproduction; RNA-dependent DNA replication; virus assembly; viral infectious cycle; platelet degranulation; positive regulation of protein secretion; entry into host cell; blood coagulation; leukocyte migration; regulation of viral genome replication
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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