product summary
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company name :
MyBioSource
product type :
antibody
product name :
COPS2 Monoclonal Antibody
catalog :
MBS2517608
quantity :
0.06 mL
price :
220 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[2H10E6]
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western Blot analysis of NIH/3T3 cells using COPS2 Monoclonal Antibody at dilution of 1:8000
product information
catalog number :
MBS2517608
products type :
Antibody
products full name :
COPS2 Monoclonal Antibody
products short name :
[COPS2]
products name syn :
[ALIEN; Alien Drosophila himolog of; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; COPS 2; Cops2; CSN2; CSN2; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; Thyroid Hormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15; TRIP15]
other names :
[COP9 signalosome complex subunit 2 isoform 2; COP9 signalosome complex subunit 2; COP9 signalosome complex subunit 2; COP9 signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15]
products gene name :
[COPS2]
other gene names :
[COPS2; COPS2; CSN2; SGN2; ALIEN; TRIP15; CSN2; TRIP15; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15]
clonality :
Monoclonal
isotype :
IgG1
clone :
[2H10E6]
host :
Mouse
reactivity :
Human, Mouse, Rat
sequence length :
450
purity :
Protein G purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:2000-1:20000. IHC: 1:50-1:500
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Fusion protein of COPS2
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3. Conjugation: Unconjugated
products categories :
Cancer; Epigenetics and Nuclear Signaling; Signal transduction
products description :
COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
ncbi gi num :
219842262
ncbi acc num :
NP_001137359.1
ncbi gb acc num :
NM_001143887.1
uniprot acc num :
P61201
ncbi mol weight :
Calculated: 52kDa. Observed: 52kDa
uniprot summary :
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
size1 :
0.06 mL
price1 :
220 USD
size2 :
0.12 mL
price2 :
290
size3 :
0.2 mL
price3 :
435
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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