CRMP2 Polyclonal Antibody | MyBioSource MBS2517600 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CRMP2 Polyclonal Antibody

catalog :

MBS2517600

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

A549 cells were subjected to SDS PAGE followed by western blot with CRMP2 Polyclonal Antibody at dilution of 1:300

image 2 :

Immunofluorescent analysis of HepG2 cell using CRMP2 Polyclonal Antibody at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

image 3 :

Immunohistochemistry of paraffinembedded human colon cancer tissue slide using CRMP2 Polyclonal Antibody at dilution of 1:200 (under 40x lens).

product information

catalog number :

MBS2517600

products type :

Antibody

products full name :

CRMP2 Polyclonal Antibody

products short name :

[DPYSL2]

products name syn :

[CRMP2; DHPRP2; DRP-2; DRP2]

other names :

[Dihydropyrimidinase-related protein 2; Dihydropyrimidinase-related protein 2; dihydropyrimidinase-related protein 2; collapsin response mediator protein hCRMP-2; unc-33-like phosphoprotein 2; dihydropyrimidinase-like 2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2]

products gene name :

[DPYSL2]

other gene names :

[DPYSL2; DPYSL2; DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2; CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2]

uniprot entry name :

DPYL2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

572

purity :

Antigen affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:200-1:1000. IHC: 1:50-1:200. IF: 1:20-1:200

image1 heading :

SDS-PAGE

image2 heading :

Immunofluorescent

image3 heading :

Immunohistochemistry

other info1 :

Immunogen: Fusion protein of CRMP2. Calculated Molecular Weight: 62kd. Observed Molecular Weight: 62 kDa

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-25893 / sc-25895

products description :

Dihydropyrimidinase-like 2 (Dpysl2), a protein involved in neuronal differentiation and axonal guidance is found altered in various nervous system diseases. It is also named as CRMP2, ULIP2 and belongs to hydantoinase/dihydropyrimidinase subfamily. The phosphorylation of the particular portion carboxyl-terminal to the basic region of DPYSL2 may play an important role in regulating its activity, and may be involved in the formation of degenerating neurites in AD brain.

ncbi gi num :

3122051

ncbi acc num :

Q16555.1

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); L1CAM Interactions Pathway (161003); Recycling Pathway Of L1 (161004); Regulation Of Microtubule Cytoskeleton Pathway (755439); Semaphorin Interactions Pathway (119519)

ncbi summary :

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

uniprot summary :

CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Protein type: Motility/polarity/chemotaxis; Microtubule-binding. Chromosomal Location of Human Ortholog: 8p22-p21. Cellular Component: microtubule; growth cone; mitochondrion; membrane; cell soma; dendrite; terminal button; cytosol. Molecular Function: protein binding; dihydropyrimidinase activity; protein kinase binding. Biological Process: response to drug; axon guidance; nervous system development; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage