antibody

STAB1 Polyclonal Antibody

MBS2517471

0.02 mL

110 USD

polyclonal

rabbit

nonconjugated

human, mouse

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

STAB1 Polyclonal Antibody

[STAB1]

[FEX1; FEEL-1; FELE-1; STAB-1; CLEVER-1]

[Stabilin-1; Stabilin-1; stabilin-1; MS-1 antigen; common lymphatic endothelial and vascular endothelial receptor-1; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1; fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1; stabilin 1; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1; FEEL-1; MS-1 antigen]

[STAB1]

[STAB1; STAB1; FEX1; FEEL-1; FELE-1; STAB-1; CLEVER-1; FEEL1; KIAA0246; FEEL-1]

STAB1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

2570

Affinity purification

0.2mg/mL

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:25-1:100

Immunohistochemistry (IHC)

Background: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node.

296452949

Q9NY15.3

87,026 Da

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging By Class H Receptors Pathway (833817)

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

STAB1: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3p21.1. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: low-density lipoprotein receptor activity; protein binding; hyaluronic acid binding; low-density lipoprotein binding; protein disulfide oxidoreductase activity; scavenger receptor activity. Biological Process: receptor-mediated endocytosis; negative regulation of angiogenesis; cell-cell signaling; defense response to bacterium; cell adhesion; inflammatory response

0.02 mL

110 USD

0.06 mL

150

0.12 mL

225

0.2 mL

360