product summary
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company name :
MyBioSource
product type :
antibody
product name :
CTSL Polyclonal Antibody
catalog :
MBS2517363
quantity :
0.06 mL
price :
195 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2517363
products type :
Antibody
products full name :
CTSL Polyclonal Antibody
products short name :
CTSL
products name syn :
MEP; CATL; CTSL1
other names :
cathepsin L1 isoform 2; Cathepsin L1; cathepsin L1; major excreted protein; cathepsin L; Cathepsin L; Major excreted protein; MEP
products gene name :
CTSL
other gene names :
CTSL; CTSL; MEP; CATL; CTSL1; CTSL1; MEP
uniprot entry name :
CATL1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
151
purity :
Antigen affinity purification
storage stability :
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
products description :
Background/Introduction: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria.
ncbi gi num :
384081596
ncbi acc num :
NP_001244902.1
ncbi gb acc num :
NM_001257973.1
ncbi mol weight :
38kDa
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); Endosomal/Vacuolar Pathway (477125)
ncbi summary :
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
uniprot summary :
CTSL1: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family. Protein type: Motility/polarity/chemotaxis; Protease; EC 3.4.22.15. Chromosomal Location of Human Ortholog: 9q21.33. Cellular Component: extracellular space; lysosomal lumen; lysosome; extracellular region; nucleus. Molecular Function: collagen binding; proteoglycan binding; protein binding; histone binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity. Biological Process: extracellular matrix disassembly; antigen processing and presentation; collagen catabolic process; extracellular matrix organization and biogenesis; adaptive immune response; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis
size1 :
0.06 mL
price1 :
195 USD
size2 :
0.12 mL
price2 :
270
size3 :
0.2 mL
price3 :
435
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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