antibody

CHRNA4 Polyclonal Antibody

MBS2517026

0.06 mL

195 USD

polyclonal

rabbit

nonconjugated

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

CHRNA4 Polyclonal Antibody

CHRNA4

EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4

CHRNA4 protein; Neuronal acetylcholine receptor subunit alpha-4; neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; cholinergic receptor, nicotinic, alpha 4 (neuronal)

CHRNA4

CHRNA4; CHRNA4; EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; NACRA4

ACHA4_HUMAN

Polyclonal

IgG

Rabbit

Human

451

Antigen affinity purification

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:50-1:200

Immunogen: Recombinant protein of human CHRNA4

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.

64654445

AAH96292.1

Acetylcholine Binding And Downstream Events Pathway (106535); Activation Of Nicotinic Acetylcholine Receptors Pathway (161027); Cholinergic Synapse Pathway (217716); Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway (161029); Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway (161032); Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway (161030); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534)

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Protein type: Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass; Channel, ligand-gated. Chromosomal Location of Human Ortholog: 20q13.33. Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; membrane; dendrite; integral to membrane; plasma membrane; cell junction; external side of plasma membrane. Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding; ligand-gated ion channel activity. Biological Process: response to nicotine; regulation of action potential; B cell activation; behavioral response to nicotine; locomotory behavior; respiratory gaseous exchange; sensory perception of pain; DNA repair; signal transduction; regulation of dopamine secretion; synaptic transmission, cholinergic; neurological system process; membrane depolarization; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; regulation of membrane potential; calcium ion transport; response to hypoxia; ion transport; response to oxidative stress; cognition. Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To

0.06 mL

195 USD

0.12 mL

270

0.2 mL

435