DRD5 Antibody | MyBioSource MBS2516950 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DRD5 Antibody

catalog :

MBS2516950

quantity :

0.06 mL

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of mouse brain tissue, using DRD5 antibody.

image 2 :

Immunofluorescence analysis of HeLa cell using DRD5 antibody. Blue: DAPI for nuclear staining.

product information

catalog number :

MBS2516950

products type :

Antibody

products full name :

DRD5 Antibody

products short name :

[DRD5]

products name syn :

[DBDR; DRD1B; DRD1L2; MGC10601]

other names :

[D(1B) dopamine receptor; D(1B) dopamine receptor; D(1B) dopamine receptor; D(1B) dopamine receptor; D1beta dopamine receptor; d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor D1B; dopamine receptor D5; D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor]

products gene name :

[DRD5]

other gene names :

[DRD5; DRD5; DBDR; DRD1B; DRD1L2; DRD1B; DRD1L2]

uniprot entry name :

DRD5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

477

purity :

Affinity purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

storage stability :

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:2000. IF: 1:50 - 1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescence

other info1 :

Immunogen: Recombinant protein of human DRD5

products description :

Background: This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

ncbi gi num :

4503391

ncbi acc num :

NP_000789.1

ncbi gb acc num :

NM_000798.4

ncbi mol weight :

Calculated MW: 52kDa. Observed MW: 53kDa

ncbi pathways :

Amine Ligand-binding Receptors Pathway (106363); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Dopamine Receptors Pathway (106366); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); G Alpha (s) Signalling Events Pathway (119549)

ncbi summary :

This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

uniprot summary :

DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 4p16.1. Cellular Component: brush border membrane; integral to plasma membrane; plasma membrane. Molecular Function: dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity. Biological Process: synaptic transmission, dopaminergic; wound healing; response to amphetamine; adenylate cyclase activation; transmission of nerve impulse; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; response to cocaine; G-protein signaling, adenylate cyclase activating pathway; cellular calcium ion homeostasis; synaptic transmission; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; sensitization; dopamine receptor, phospholipase C activating pathway; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; associative learning; dopamine receptor, adenylate cyclase activating pathway. Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential

size1 :

0.06 mL

price1 :

150 USD

size2 :

0.12 mL

price2 :

225

size3 :

0.2 mL

price3 :

360

more info or order :

MyBioSource product webpage