catalog number :
MBS2516854
products full name :
CCS Polyclonal Antibody
products short name :
[CCS]
other names :
[copper chaperone for superoxide dismutase; Copper chaperone for superoxide dismutase; copper chaperone for superoxide dismutase; superoxide dismutase copper chaperone; copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone]
products gene name :
[CCS]
other gene names :
[CCS; CCS]
uniprot entry name :
CCS_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen affinity purification
storage stability :
Store at -20°. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:25-1:100
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Synthetic peptide of human CCS. Calculated Molecular Weight: 29kDa
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products description :
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
ncbi acc num :
NP_005116.1
ncbi gb acc num :
NM_005125.1
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552)
ncbi summary :
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]
uniprot summary :
CCS: Delivers copper to copper zinc superoxide dismutase (SOD1). Chromosomal Location of Human Ortholog: 11q13. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: copper ion transmembrane transporter activity; protein binding; copper ion binding; zinc ion binding; superoxide dismutase activity; protein disulfide oxidoreductase activity. Biological Process: response to reactive oxygen species; removal of superoxide radicals; superoxide metabolic process; intracellular copper ion transport; positive regulation of oxidoreductase activity