catalog number :
MBS2516763
products full name :
AURKAIP1 Polyclonal Antibody
products short name :
[AURKAIP1]
products name syn :
[AIP; AKIP; MRP-S38]
other names :
[AURKAIP1 protein, partial; Aurora kinase A-interacting protein; aurora kinase A-interacting protein; 28S ribosomal protein S38, mitochondrial; AURKA-interacting protein; aurora-A kinase interacting protein; aurora kinase A interacting protein 1; 28S ribosomal protein S38, mitochondrial; MRP-S38]
products gene name :
[AURKAIP1]
other gene names :
[AURKAIP1; AURKAIP1; AIP; AKIP; MRP-S38; AIP; AKIP; MRPS38; AURKA-interacting protein; MRP-S38]
uniprot entry name :
AKIP_HUMAN
purity :
Affinity purification
form :
PBS with 0.05% sodium azide, 50% glycerol, pH 7.3
storage stability :
Store at -20°C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
Western Blot: 1:500-1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human AURKAIP1
other info2 :
Note: Centrifuge before opening to ensure complete recovery of vial contents.
products categories :
Cell biology
products description :
AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
ncbi pathways :
Aurora A Signaling Pathway (137925); Mitochondrial Translation Pathway (1127498); Mitochondrial Translation Elongation Pathway (1127500); Mitochondrial Translation Initiation Pathway (1127499); Mitochondrial Translation Termination Pathway (1127501); Organelle Biogenesis And Maintenance Pathway (1127494)
uniprot summary :
AKIP: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 1p36.33. Cellular Component: nucleoplasm; mitochondrion; intracellular membrane-bound organelle; mitochondrial inner membrane; nucleus. Molecular Function: protein binding. Biological Process: mitochondrial translation; positive regulation of proteolysis; organelle organization and biogenesis; negative regulation of mitosis