Human CCR4(Chemokine C-X-C-Motif Receptor)ELISA Kit | MyBioSource MBS2516056 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human CCR4(Chemokine C-X-C-Motif Receptor)ELISA Kit

catalog :

MBS2516056

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2516056

products type :

ELISA Kit

products full name :

Human CCR4(Chemokine C-X-C-Motif Receptor)ELISA Kit

products short name :

[CCR4]

other names :

[C-C chemokine receptor type 4; C-C chemokine receptor type 4; C-C chemokine receptor type 4; C-C CKR-4; CCR-4; chemokine (C-C) receptor 4; chemokine (C-C motif) receptor 4; K5-5; CD_antigen: CD194]

products gene name :

[CXCR4]

other gene names :

[CCR4; CCR4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; CMKBR4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4]

uniprot entry name :

CCR4_HUMAN

reactivity :

Human

sequence length :

360

specificity :

This kit recognizes natural and recombinantHumanCXCR4. No significant cross-reactivity or interference between HumanCXCR4 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 78.125-5000pg/mL. Sensitivity: Min: 46.875pg/mL; Max: 5000pg/mL

products description :

Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanCXCR4concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CXCR4. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CXCR4and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CXCR4, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CXCR4.You can calculate the concentration of CXCR4in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

1705894

ncbi acc num :

P51679.1

ncbi mol weight :

41,403 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

uniprot summary :

CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 3p24. Cellular Component: cell soma; integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: C-C chemokine receptor activity; chemokine receptor activity. Biological Process: response to antibiotic; G-protein coupled receptor protein signaling pathway; response to radiation; elevation of cytosolic calcium ion concentration; positive regulation of positive chemotaxis; response to bacterium; neuron migration; immune response; chemotaxis; inflammatory response; tolerance induction

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590