This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
ELISA/assay
product name :
Human SESN1(Sestrin 1)ELISA Kit
catalog :
MBS2515855
quantity :
24-Strip-Wells
price :
215 USD
product information
catalog number :
MBS2515855
products type :
ELISA Kit
products full name :
Human SESN1(Sestrin 1)ELISA Kit
products short name :
[SESN1]
other names :
[Sestrin-1; Sestrin-1; sestrin-1; p53 activated gene 26; p53 regulated PA26 nuclear protein; sestrin 1; p53-regulated protein PA26]
products gene name :
[SESN1]
other gene names :
[SESN1; SESN1; PA26; SEST1; PA26; SEST1]
uniprot entry name :
SESN1_HUMAN
reactivity :
Human
sequence length :
492
specificity :
This kit recognizes natural and recombinantHumanSESN1. No significant cross-reactivity or interference between HumanSESN1 and analogues was observed.
storage stability :
Store at 4 degree C.
image1 heading :
Typical Testing Data/Standard Curve (for reference only)
other info1 :
Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL
products description :
Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanSESN1concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to SESN1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for SESN1and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain SESN1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of SESN1.You can calculate the concentration of SESN1in the samples by comparing the OD of the samples to the standard curve.
ncbi gi num :
13633953
ncbi acc num :
Q9Y6P5.2
ncbi mol weight :
49,624 Da
ncbi pathways :
DNA Damage Response Pathway (198788); Direct P53 Effectors Pathway (137939); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)
ncbi summary :
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
uniprot summary :
SESN1: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. Belongs to the sestrin family. 3 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: nucleus. Biological Process: negative regulation of cell proliferation; regulation of protein kinase B signaling cascade; cell cycle arrest; response to DNA damage stimulus
size1 :
24-Strip-Wells
price1 :
215 USD
size2 :
48-Strip-Wells
price2 :
410
size3 :
96-Strip-Wells
price3 :
490
size4 :
5x96-Strip-Wells
price4 :
2040
size5 :
10x96-Strip-Wells
price5 :
3590
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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