Rat esRAGE(Endogenous secretory Advanced Glycosylation End Product Specific Receptor)ELISA Kit | MyBioSource MBS2515623 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat esRAGE(Endogenous secretory Advanced Glycosylation End Product Specific Receptor)ELISA Kit

catalog :

MBS2515623

quantity :

24-Strip-Wells

price :

215 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2515623

products type :

ELISA Kit

products full name :

Rat esRAGE(Endogenous secretory Advanced Glycosylation End Product Specific Receptor)ELISA Kit

products short name :

[esRAGE]

other names :

[endogenous secretory receptor for advanced glycation endproducts; Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor; advanced glycation end-products receptor; receptor for advanced glycation end-products variant 20; receptor for advanced glycosylation end products; advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products]

products gene name :

[esRAGE]

other gene names :

[Ager; Ager; RAGE; Rage]

uniprot entry name :

RAGE_MOUSE

reactivity :

Rat

sequence length :

334

specificity :

This kit recognizes Rat esRAGE in samples. No Significant cross-reactivity or interference between Rat esRAGE and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat esRAGE were tested 20 times on one plate, respectively. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat esRAGE were tested on 3 different plates, 20 replicates in each plate.

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Rat esRAGE concentrations in serum, plasma and other biological fluids.

ncbi gi num :

84570471

ncbi acc num :

BAE72665.1

ncbi mol weight :

42,669 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (1110727); Advanced Glycosylation Endproduct Receptor Signaling Pathway (1110746); Cytosolic Sensors Of Pathogen-associated DNA Pathway (1110756); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (1110764); Immune System Pathway (1110668); Innate Immune System Pathway (1110697); MyD88 Cascade Initiated On Plasma Membrane Pathway (1110701); MyD88 Dependent Cascade Initiated On Endosome Pathway (1110719); MyD88-independent Cascade Pathway (1110711); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (1110728)

uniprot summary :

RAGE: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell cycle regulation; Membrane protein, integral. Cellular Component: extracellular space; cell surface; cell soma; membrane; axon; cytoplasm; basal plasma membrane; integral to membrane; plasma membrane; cytosol. Molecular Function: identical protein binding; protein binding; advanced glycation end-product receptor activity. Biological Process: positive regulation of JNK activity; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; negative regulation of collagen biosynthetic process; negative regulation of cell adhesion; JAK-STAT cascade; positive regulation of smooth muscle cell migration; induction of positive chemotaxis; activation of NF-kappaB transcription factor; calcium ion homeostasis; positive regulation of fibroblast proliferation; negative regulation of protein amino acid phosphorylation; regulation of DNA binding; positive regulation of neuron apoptosis; negative regulation of endothelial cell proliferation; regulation of inflammatory response; response to hypoxia; positive regulation of protein amino acid phosphorylation; positive regulation of phagocytosis, engulfment; inflammatory response; positive regulation of autophagy; neurite development; positive regulation of inflammatory response; positive regulation of cell migration

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590

more info or order :

MyBioSource product webpage