catalog number :
MBS251540
products type :
Recombinant Protein
products full name :
Collagenase 3
products short name :
Collagenase 3
other names :
collagenase 3 preproprotein; Collagenase 3; collagenase 3; matrix metalloproteinase 13 (collagenase 3); matrix metallopeptidase 13 (collagenase 3); Matrix metalloproteinase-13; MMP-13
products gene name :
Collagenase 3
other gene names :
MMP13; MMP13; CLG3; MANDP1; MMP-13; MMP-13
uniprot entry name :
MMP13_HUMAN
sequence :
YNVFPRTLKWSQTNLTYRIVNYTPDMSHSEVEKAFRKAF
KVWSDVTPLNFTRIYDGTADIMISFGTKEHGDFYPFDGP
SGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFIVA
AHELGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDV
QGIQFLYGPGDEDPNPKHPKTPEKCDPALSLDAITSLRG
ETMIFKDRFFWRLHPQQVEAELFLTKSFWPELPNHVDAA
YEHPSRDLMFIFRGRKFWALNGYDILEGYPRKISDLGFP
KEVKRLSAAVHFENTGKTLFFSENHVWSYDDVNQTMDKD
YPRLIEEEFPGIGNKVDAVYEKNGYIYFFNGPIQFEYSI
WSNRIVRVMPTNSILWC
form :
Supplied in solution; 20mM Tris-HCl, 0.5M Arg, pH 8.0, 50% glycerol.
storage stability :
Store at 2-8 degree C for one month; for long term storage, store at -20 degree C or -80 degree C.
other info1 :
Tag Information: His tag
other info2 :
Organism: Mus musculus (Mouse)
products description :
Degrades collagen type I
ncbi acc num :
NP_002418.1
ncbi gb acc num :
NM_002427.3
ncbi pathways :
AGE/RAGE Pathway 698754!!Activation Of Matrix Metalloproteinases Pathway 576264!!Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway 730306!!Collagen Degradation Pathway 730309!!Collagen Formation Pathway 645288!!Degradation Of The Extracellular Matrix Pathway 576263!!Endochondral Ossification Pathway 198812!!Extracellular Matrix Organization Pathway 576262!!Matrix Metalloproteinases Pathway 198900!!Oncostatin M Signaling Pathway 711361
ncbi summary :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]