Human AQP-3 (Aquaporin 3) ELISA Kit | MyBioSource MBS2515039 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human AQP-3 (Aquaporin 3) ELISA Kit

catalog :

MBS2515039

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2515039

products type :

ELISA Kit

products full name :

Human AQP-3 (Aquaporin 3) ELISA Kit

products short name :

[AQP-3]

other names :

[aquaporin-3; Aquaporin-3; aquaporin-3; aquaglyceroporin-3; aquaporin 3 (GIL blood group); aquaporin 3 (Gill blood group); Aquaglyceroporin-3]

products gene name :

[AQP-3]

other gene names :

[AQP3; AQP3; GIL; AQP-3; AQP-3]

uniprot entry name :

AQP3_HUMAN

reactivity :

Human

sequence length :

292

specificity :

This kit recognizes natural and recombinantHumanAQP-3. No significant cross-reactivity or interference between HumanAQP-3 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanAQP-3concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to AQP-3. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for AQP-3and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain AQP-3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of AQP-3.You can calculate the concentration of AQP-3in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

4826645

ncbi acc num :

NP_004916.1

ncbi gb acc num :

NM_004925.4

uniprot acc num :

Q92482

ncbi mol weight :

29,987 Da

ncbi pathways :

Aquaporin-mediated Transport Pathway (187187); Passive Transport By Aquaporins Pathway (187188); Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway (137918); Transmembrane Transport Of Small Molecules Pathway (106572); Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway (187189); Vasopressin-regulated Water Reabsorption Pathway (143700); Vasopressin-regulated Water Reabsorption Pathway (143631)

ncbi summary :

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

uniprot summary :

AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, aquaporin family; Channel, misc.; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; intercellular junction. Molecular Function: transporter activity; urea transmembrane transporter activity; water channel activity; glycerol channel activity. Biological Process: positive regulation of immune system process; glycerol transport; cellular water homeostasis; response to retinoic acid; water transport; excretion; odontogenesis; response to vitamin D; transport; renal water homeostasis; response to calcium ion; regulation of keratinocyte differentiation; transmembrane transport. Disease: Gil Blood Group

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590