Human COLEC11 (Collectin Sub-Family Member 11) ELISA Kit | MyBioSource MBS2514561 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human COLEC11 (Collectin Sub-Family Member 11) ELISA Kit

catalog :

MBS2514561

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2514561

products type :

ELISA Kit

products full name :

Human COLEC11 (Collectin Sub-Family Member 11) ELISA Kit

products short name :

[COLEC11]

other names :

[collectin-11 isoform j; Collectin-11; collectin-11; Collectin K1; collectin kidney protein 1; collectin sub-family member 11; Collectin kidney protein 1; CL-K1]

products gene name :

[COLEC11]

other gene names :

[COLEC11; COLEC11; 3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CL-K1]

uniprot entry name :

COL11_HUMAN

reactivity :

Human

sequence length :

197

specificity :

This kit recognizes natural and recombinant Human COLEC11. No significant cross-reactivity or interference between Human COLEC11 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 15.625-1000pg/mL. Sensitivity: Min: 9.375pg/mL; Max: 1000pg/mL

products description :

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to COLEC11. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for COLEC11 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain COLEC11, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of COLEC11. You can calculate the concentration of COLEC11 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

364502955

ncbi acc num :

NP_001242918.1

ncbi gb acc num :

NM_001255989.1

uniprot acc num :

Q9BWP8

ncbi mol weight :

30,200 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Phagosome Pathway (153910); Phagosome Pathway (153859); Scavenging By Class A Receptors Pathway (833814)

ncbi summary :

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

uniprot summary :

COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2p25.3. Cellular Component: collagen; extracellular region. Molecular Function: mannose binding. Biological Process: receptor-mediated endocytosis; multicellular organismal development; developmental process. Disease: 3mc Syndrome 2

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590