Human C1q (Complement 1q) ELISA Kit | MyBioSource MBS2514458 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human C1q (Complement 1q) ELISA Kit

catalog :

MBS2514458

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2514458

products type :

ELISA Kit

products full name :

Human C1q (Complement 1q) ELISA Kit

products short name :

[C1q]

other names :

[complement C1q subcomponent subunit C; Complement C1q subcomponent subunit C; complement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide; complement component 1, q subcomponent, C chain]

products gene name :

[C1q]

other gene names :

[C1QC; C1QC; C1QG; C1Q-C; C1QG]

uniprot entry name :

C1QC_HUMAN

reactivity :

Human

sequence length :

245

specificity :

This kit recognizes Human BNP in samples. No significant cross-reactivity or interference between Human BNP and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma And Other Biological Fluids. Assay Type: Quantitative Competitive. Detection Range: 31.25-2000pg/mL. Sensitivity: 18.75pg/mL.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Human BNP were tested 20 times on one plate, respectively. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Human BNP were tested on 3 different plates, 20 replicates in each plate.

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human BNP concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses the Competitive-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with Human BNP. During the reaction, Human BNP in the sample or standard competes with a fixed amount of Human BNP on the solid phase supporter for sites on the Biotinylated Detection Ab specific to Human BNP. Excess conjugate and unbound sample or standard are washed from the plate, and Avidin conjugated to Horseradish Peroxidase (HRP) are added to each microplate well and incubated. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of Human BNP in the samples is then determined by comparing the OD of the samples to the standard curve.

ncbi gi num :

166235903

ncbi acc num :

NP_001107573.1

ncbi gb acc num :

NM_001114101.1

uniprot acc num :

P02747

ncbi mol weight :

25,774 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: extracellular space; collagen; extracellular region. Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; complement activation; negative regulation of granulocyte differentiation. Disease: C1q Deficiency

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590