Rat EPCR(Endothelial Protein C Receptor)ELISA Kit | MyBioSource MBS2514218 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat EPCR(Endothelial Protein C Receptor)ELISA Kit

catalog :

MBS2514218

quantity :

48-Strip-Wells

price :

410 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2514218

products type :

ELISA Kit

products full name :

Rat EPCR(Endothelial Protein C Receptor)ELISA Kit

products short name :

EPCR

other names :

endothelial protein C receptor; Endothelial protein C receptor; endothelial protein C receptor; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome-associated protein; centrocyclin; protein C receptor, endothelial; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD_antigen: CD201

products gene name :

EPCR

other gene names :

PROCR; PROCR; CCCA; EPCR; CCD41; EPCR; APC receptor

uniprot entry name :

EPCR_HUMAN

reactivity :

Rat

sequence length :

238

specificity :

This assay has high sensitivity and excellent specificity for detection of Rat EPCR. No significant cross-reactivity or interference between Rat EPCR and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat EPCR and all the analogues, therefore, cross reaction may still exist.

storage stability :

Store at 4 degree C.

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156--10ng/mL. Sensitivity: 0.094ng/mL

products description :

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of EPCR in Rat serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat EPCR. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Rat EPCR and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat EPCR, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Rat EPCR. You can calculate the concentration of Rat EPCR in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

34335272

ncbi acc num :

NP_006395.2

ncbi gb acc num :

NM_006404.4

uniprot acc num :

Q9UNN8

ncbi mol weight :

26,671 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); Common Pathway (106060); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028)

ncbi summary :

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

uniprot summary :

EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: centrosome; focal adhesion; cell surface; integral to plasma membrane; extracellular region; plasma membrane. Molecular Function: protein binding; receptor activity. Biological Process: antigen processing and presentation; immune response; blood coagulation; negative regulation of coagulation; leukocyte migration

size1 :

48-Strip-Wells

price1 :

410 USD

size2 :

96-Strip-Wells

price2 :

490

more info or order :

MyBioSource product webpage