Mouse PK2 (Prokineticin 2) ELISA Kit | MyBioSource MBS2513207 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse PK2 (Prokineticin 2) ELISA Kit

catalog :

MBS2513207

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2513207

products type :

ELISA Kit

products full name :

Mouse PK2 (Prokineticin 2) ELISA Kit

products short name :

[PK2]

other names :

[prokineticin-2 isoform a; Prokineticin-2; prokineticin-2; protein Bv8 homolog; prokineticin 2; Protein Bv8 homolog]

products gene name :

[PK2]

other gene names :

[PROK2; PROK2; BV8; HH4; PK2; KAL4; MIT1; BV8; PK2]

uniprot entry name :

PROK2_HUMAN

reactivity :

Mouse

sequence length :

129

specificity :

This kit recognizes natural and recombinantMousePK2. No significant cross-reactivity or interference between MousePK2 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL

products description :

Intended Uses: This ELISA kit applies to the invitro quantitative determination of MousePK2concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to PK2. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for PK2and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain PK2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of PK2.You can calculate the concentration of PK2in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

187167261

ncbi acc num :

NP_001119600.1

ncbi gb acc num :

NM_001126128.1

uniprot acc num :

Q9HC23

ncbi mol weight :

11,659 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114)

ncbi summary :

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

PROK2: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. Defects in PROK2 are the cause of Kallmann syndrome type 4 (KAL4); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL4 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip/palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the AVIT (prokineticin) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3p13. Cellular Component: extracellular region. Molecular Function: G-protein-coupled receptor binding. Biological Process: circadian rhythm; G-protein coupled receptor protein signaling pathway; cell proliferation; elevation of cytosolic calcium ion concentration; activation of MAPK activity; neuropeptide signaling pathway; spermatogenesis; positive regulation of smooth muscle contraction; angiogenesis; sensory perception of pain; inflammatory response; chemotaxis; negative regulation of apoptosis. Disease: Hypogonadotropic Hypogonadism 4 With Or Without Anosmia

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590