Human TL1A (Tumor Necrosis Factor Related Ligand 1A) ELISA Kit | MyBioSource MBS2512377 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human TL1A (Tumor Necrosis Factor Related Ligand 1A) ELISA Kit

catalog :

MBS2512377

quantity :

48-Strip-Wells

price :

410 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2512377

products type :

ELISA Kit

products full name :

Human TL1A (Tumor Necrosis Factor Related Ligand 1A) ELISA Kit

products short name :

TL1A

other names :

tumor necrosis factor ligand superfamily member 15 isoform VEGI-251; Tumor necrosis factor ligand superfamily member 15; tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A; tumor necrosis factor (ligand) superfamily, member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitorCleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form

products gene name :

TL1A

other gene names :

TNFSF15; TNFSF15; TL1; TL1A; VEGI; VEGI192A; TL1; VEGI

uniprot entry name :

TNF15_HUMAN

reactivity :

Human

sequence length :

251

specificity :

This kit recognizes natural and recombinant Human TL1A. No significant cross-reactivity or interference between Human TL1A and analogues was observed.

storage stability :

Store at 4 degree C.

other info1 :

Samples: Serum, plasma and other biological fluids. Assay Type: Sandwich. Detection Range: 78.125-5000pg/ml. Sensitivity: The minimum detectable dose of Human TL1A is 46.875pg/ml

products description :

Intended Uses This ELISA kit applies to the in vitro quantitative determination of Human TL1A concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to TL1A. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for TL1A and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TL1A, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of TL1A. You can calculate the concentration of TL1A in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

23510445

ncbi acc num :

NP_005109.2

ncbi gb acc num :

NM_005118.3

uniprot acc num :

O95150

ncbi mol weight :

20,131 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Senescence And Autophagy Pathway (198780)

ncbi summary :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

uniprot summary :

TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine; Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 9q32. Cellular Component: extracellular space; integral to plasma membrane; integral to membrane; plasma membrane. Molecular Function: death receptor binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: caspase activation; cytokine metabolic process; activation of NF-kappaB-inducing kinase; immune response; signal transduction; positive regulation of cytokine secretion

size1 :

48-Strip-Wells

price1 :

410 USD

size2 :

96-Strip-Wells

price2 :

490

more info or order :

MyBioSource product webpage