Human GM-CSF Ab (Anti-Granulocyte Macrophage Colony Stimulating Factor Antibody) ELISA Kit | MyBioSource MBS2511613 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human GM-CSF Ab (Anti-Granulocyte Macrophage Colony Stimulating Factor Antibody) ELISA Kit

catalog :

MBS2511613

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2511613

products type :

ELISA Kit

products full name :

Human GM-CSF Ab (Anti-Granulocyte Macrophage Colony Stimulating Factor Antibody) ELISA Kit

products short name :

[GM-CSF Ab]

other names :

[granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116 antigen; GM-CSF receptor alpha subunit; GMCSFR-alpha; GMR-alpha; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CDw116; CD_antigen: CD116]

products gene name :

[GM-CSF Ab]

other gene names :

[CSF2RA; CSF2RA; GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha; CSF2R; CSF2RY; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha]

uniprot entry name :

CSF2R_HUMAN

reactivity :

Human

sequence length :

410

specificity :

This kit recognizes natural and recombinant Human GM-CSF Ab. No significant cross-reactivity or interference between Human GM-CSF Ab and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.625-40ng/mL. Sensitivity: Min: 0.375ng/mL; Max: 40ng/mL

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human GM-CSF Ab concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antigen specific to GM-CSF Ab. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antigen. Then a biotinylated detection antigen specific for GM-CSF Ab and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain GM-CSF Ab, biotinylated detection antigen and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of GM-CSF Ab.You can calculate the concentration of GM-CSF Ab in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

238908519

ncbi acc num :

NP_001155003.1

ncbi gb acc num :

NM_001161531.1

ncbi mol weight :

31,101 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Beta:gamma Signalling Through PI3Kgamma Pathway (119540); G-protein Beta:gamma Signalling Pathway (119539); GPCR Downstream Signaling Pathway (119548); GPVI-mediated Activation Cascade Pathway (106036); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (106028)

ncbi summary :

The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]

uniprot summary :

CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3. Cellular Component: integral to plasma membrane; plasma membrane; extracellular region. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; receptor activity. Biological Process: response to ethanol; cytokine and chemokine mediated signaling pathway. Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590