Human FLNC (Filamin C, Gamma) ELISA Kit | MyBioSource MBS2511588 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human FLNC (Filamin C, Gamma) ELISA Kit

catalog :

MBS2511588

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2511588

products type :

ELISA Kit

products full name :

Human FLNC (Filamin C, Gamma) ELISA Kit

products short name :

[FLNC]

other names :

[filamin-C isoform a; Filamin-C; filamin-C; ABP-280-like protein; ABP-L, gamma filamin; actin binding protein 280; filamin-2; filamin C, gamma; ABP-280-like protein; ABP-L; Actin-binding-like protein; Filamin-2; Gamma-filamin]

products gene name :

[FLNC]

other gene names :

[FLNC; FLNC; ABPA; ABPL; FLN2; MFM5; MPD4; ABP-280; ABP280A; ABPL; FLN2; FLN-C; FLNc]

uniprot entry name :

FLNC_HUMAN

reactivity :

Human

sequence length :

2725

specificity :

This assay has high sensitivity and excellent specificity for detection of Human FLNC. No significant cross-reactivity or interference between Human FLNC and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human FLNC and all the analogues, therefore, cross reaction may still exist.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FLNC in human serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human FLNC. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human FLNC and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human FLNC, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human FLNC. You can calculate the concentration of Human FLNC in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

116805322

ncbi acc num :

NP_001449.3

ncbi gb acc num :

NM_001458.4

uniprot acc num :

Q14315

ncbi mol weight :

287,281 Da

ncbi pathways :

Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-extracellular Matrix Interactions Pathway (160967); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054); Salmonella Infection Pathway (375172)

ncbi summary :

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

FLNC: Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Defects in FLNC are the cause of myopathy myofibrillar type 5 (MFM5). A neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations, and clinical features of a limb-girdle myopathy. Defects in FLNC are the cause of myopathy distal type 4 (MPD4). MPD4 is a slowly progressive muscular disorder characterized by distal muscle weakness and atrophy affecting the upper and lower limbs. Onset occurs around the third to fourth decades of life, and patients remain ambulatory even after long disease duration. Muscle biopsy shows non-specific changes with no evidence of rods, necrosis, or inflammation. Belongs to the filamin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 7q32-q35. Cellular Component: costamere; cytoskeleton; focal adhesion; cytoplasm; plasma membrane; sarcoplasm; Z disc; cytosol; sarcolemma. Molecular Function: actin filament binding; protein binding; cytoskeletal protein binding; ankyrin binding. Biological Process: muscle fiber development. Disease: Myopathy, Myofibrillar, 5; Myopathy, Distal, 4

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590