ELISA/assay

Human NTRK3 (Neurotrophic Tyrosine Kinase Receptor Type 3) ELISA Kit

MBS2511393

48-Strip-Wells

410 USD

ELISA Kit

Human NTRK3 (Neurotrophic Tyrosine Kinase Receptor Type 3) ELISA Kit

NTRK3

NT-3 growth factor receptor isoform d; NT-3 growth factor receptor; NT-3 growth factor receptor; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; tyrosine kinase receptor C; neurotrophic tyrosine kinase, receptor, type 3; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase

NTRK3

NTRK3; NTRK3; TRKC; gp145(trkC); TRKC; Trk-C

NTRK3_HUMAN

Human

817

This assay has high sensitivity and excellent specificity for detection of Human NTRK3. No significant cross-reactivity or interference between Human NTRK3 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human NTRK3 and all the analogues, therefore, cross reaction may still exist.

Store at 4 degree C.

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 3.125--200ng/mL. Sensitivity: 1.875ng/mL

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of NTRK3 in human serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human NTRK3. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human NTRK3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human NTRK3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human NTRK3. You can calculate the concentration of Human NTRK3 in the samples by comparing the OD of the samples to the standard curve.

340745353

NP_001230030.1

NM_001243101.1

Q16288

91,833 Da

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; TK group; Trk family. Chromosomal Location of Human Ortholog: 15q25. Cellular Component: integral to plasma membrane; cytoplasm; receptor complex. Molecular Function: neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding. Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of axon extension involved in regeneration; activation of protein kinase B; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus; positive regulation of cell migration

48-Strip-Wells

410 USD

96-Strip-Wells

490