Human LILRB4 (Leukocyte Immunoglobulin Like Receptor Subfamily B Member 4) ELISA Kit | MyBioSource MBS2511025 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human LILRB4 (Leukocyte Immunoglobulin Like Receptor Subfamily B Member 4) ELISA Kit

catalog :

MBS2511025

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2511025

products type :

ELISA Kit

products full name :

Human LILRB4 (Leukocyte Immunoglobulin Like Receptor Subfamily B Member 4) ELISA Kit

products short name :

[LILRB4]

other names :

[leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor subfamily B member 4; CD85 antigen-like family member K; immunoglobulin-like transcript 3; leukocyte immunoglobulin-like receptor 5; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; Monocyte inhibitory receptor HM18; CD_antigen: CD85k]

products gene name :

[LILRB4]

other gene names :

[LILRB4; LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5; ILT3; LIR5; ILT-3; LIR-5]

uniprot entry name :

LIRB4_HUMAN

reactivity :

Human

sequence length :

254

specificity :

This kit recognizes natural and recombinant Human LILRB4. No significant cross-reactivity or interference between Human LILRB4 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human LILRB4 concentrations in serum, plasma and other biological fluids. Principle of the Assay This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to LILRB4. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for LILRB4 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain LILRB4, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of LILRB4. You can calculate the concentration of LILRB4 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

510025453

ncbi acc num :

NP_001265359.1

ncbi gb acc num :

NM_001278430.2

uniprot acc num :

Q8NHJ6

ncbi mol weight :

49,397 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096)

ncbi summary :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: integral to membrane; plasma membrane. Molecular Function: protein binding; receptor activity; antigen binding. Biological Process: negative regulation of osteoclast differentiation; immune system process; signal transduction

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590