Human RIPK2 (Receptor TNFRSF Interacting Serine Threonine Kinase 2) ELISA Kit | MyBioSource MBS2510137 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human RIPK2 (Receptor TNFRSF Interacting Serine Threonine Kinase 2) ELISA Kit

catalog :

MBS2510137

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2510137

products type :

ELISA Kit

products full name :

Human RIPK2 (Receptor TNFRSF Interacting Serine Threonine Kinase 2) ELISA Kit

products short name :

[RIPK2]

other names :

[receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting serine/threonine-protein kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; RIP-2; growth-inhibiting gene 30; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting protein 2; tyrosine-protein kinase RIPK2; receptor-interacting serine-threonine kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2 (EC:2.7.10.2)]

products gene name :

[RIPK2]

other gene names :

[RIPK2; RIPK2; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2]

uniprot entry name :

RIPK2_HUMAN

reactivity :

Human

sequence length :

540

specificity :

This kit recognizes Human REG3gamma in samples. No significant cross-reactivity or interference between Human REG3gamma and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma And Other Biological Fluids. Assay Type: Quantitative Sandwich. Detection Range: 1.56-100ng/mL. Sensitivity: 0.94ng/mL.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Human REG3gamma were tested 20 times on one plate, respectively. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Human REG3gamma were tested on 3 different plates, 20 replicates in each plate.

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human REG3gamma concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human REG3gamma. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human REG3gamma and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human REG3gamma, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human REG3gamma. You can calculate the concentration of Human REG3gamma in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

4506537

ncbi acc num :

NP_003812.1

ncbi gb acc num :

NM_003821.5

uniprot acc num :

O43353

ncbi mol weight :

45,582 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Adaptive Immune System Pathway (366160); Canonical NF-kappaB Pathway (138030); Cytokine Signaling In Immune System Pathway (366171); Downstream TCR Signaling Pathway (106418); FAS Pathway And Stress Induction Of HSP Regulation (198894); IL12-mediated Signaling Events Pathway (137922); Immune System Pathway (106386); Innate Immune System Pathway (106387); Interleukin-1 Signaling Pathway (160141)

ncbi summary :

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

uniprot summary :

RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, TKL; EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: cytoskeleton; protein complex; cytoplasm; cytosol; vesicle. Molecular Function: protein serine/threonine kinase activity; signal transducer activity; LIM domain binding; protein binding; protein homodimerization activity; non-membrane spanning protein tyrosine kinase activity; CARD domain binding; ATP binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; positive regulation of interleukin-12 production; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; signal transduction; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; T cell proliferation; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; positive regulation of immature T cell proliferation; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of interferon-gamma production; defense response to Gram-positive bacterium; positive regulation of protein ubiquitination; toll-like receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of T-helper 1 cell differentiation; negative regulation of apoptosis

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590