Human Gas6 (Growth Arrest Specific Protein 6) ELISA Kit | MyBioSource MBS2509898 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Gas6 (Growth Arrest Specific Protein 6) ELISA Kit

catalog :

MBS2509898

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2509898

products type :

ELISA Kit

products full name :

Human Gas6 (Growth Arrest Specific Protein 6) ELISA Kit

products short name :

[Gas6]

other names :

[Growth arrest-specific protein 6; growth arrest-specific protein 6; growth arrest-specific 6; AXL receptor tyrosine kinase ligand]

products gene name :

[Gas6]

other gene names :

[GAS6; GAS6; AXSF; AXLLG; AXLLG; GAS-6]

uniprot entry name :

GAS6_HUMAN

reactivity :

Human

sequence length :

379

specificity :

This kit recognizes natural and recombinant Human Gas6. No significant cross-reactivity or interference between Human Gas6 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 62.5-4000pg/mL. Sensitivity: Min: 37.5pg/mL; Max: 4000pg/mL

products description :

Intended Uses This ELISA kit applies to the in vitro quantitative determination of Human Gas6 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Gas6. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Gas6 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Gas6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Gas6. You can calculate the concentration of Gas6 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

221316738

ncbi acc num :

NP_001137418.1

ncbi gb acc num :

NM_001143946.1

uniprot acc num :

Q14393

ncbi mol weight :

41,986 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (106231); Gamma-carboxylation Of Protein Precursors Pathway (106233); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (106232); Hemostasis Pathway (106028); Metabolism Of Proteins Pathway (106230); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Post-translational Protein Modification Pathway (161012); Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway (106235)

ncbi summary :

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

uniprot summary :

GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Ligand, receptor tyrosine kinase; Secreted. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; cytoplasm; extracellular region. Molecular Function: voltage-gated calcium channel activity; protein binding; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding. Biological Process: entry of virus into host cell; neuron migration; negative regulation of caspase activity; signal transduction; proteolysis; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; platelet degranulation; negative regulation of protein import into nucleus, translocation; positive regulation of glomerular filtration; regulation of growth; positive regulation of phagocytosis; negative regulation of interferon-gamma production; protein kinase B signaling cascade; negative regulation of interleukin-6 production; cell adhesion; cell cycle arrest; positive regulation of TOR signaling pathway; platelet activation; virion attachment, binding of host cell surface receptor; cell migration; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; negative regulation of tumor necrosis factor production; viral genome replication; cellular response to starvation; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; negative regulation of transcription, DNA-dependent; negative regulation of interleukin-1 secretion; leukocyte migration; apoptotic cell clearance; negative regulation of apoptosis

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590