Mouse PDGF-AA (Platelet-Derived Growth Factor-AA) ELISA Kit | MyBioSource MBS2509542 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse PDGF-AA (Platelet-Derived Growth Factor-AA) ELISA Kit

catalog :

MBS2509542

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2509542

products type :

ELISA Kit

products full name :

Mouse PDGF-AA (Platelet-Derived Growth Factor-AA) ELISA Kit

products short name :

[PDGF-AA]

other names :

[Platelet-derived growth factor receptor alpha; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor alpha; CD140 antigen-like family member A; CD140a antigen; PDGF-R-alpha; PDGFRA/BCR fusion; alpha-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 2; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; platelet-derived growth factor receptor, alpha polypeptide; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD_antigen: CD140a]

products gene name :

[PDGF-AA]

other gene names :

[PDGFRA; PDGFRA; CD140A; PDGFR2; PDGFR-2; RHEPDGFRA; PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2]

uniprot entry name :

PGFRA_HUMAN

reactivity :

Mouse

sequence length :

1089

specificity :

This kit recognizes Mouse PAP in samples. No significant cross-reactivity or interference between Mouse PAP and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma And Other Biological Fluids. Assay Type: Quantitative Sandwich. Detection Range: 3.13-200ng/mL. Sensitivity: 1.88ng/mL.

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of MousePAP concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse PAP. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Mouse PAP and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse PAP, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse PAP. You can calculate the concentration of Mouse PAP in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

129892

ncbi acc num :

P16234.1

ncbi mol weight :

82,809 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Adaptive Immune System Pathway (366160); Angiogenesis Pathway (198772); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Progenitor Differentiation Pathway (712094); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232)

ncbi summary :

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

uniprot summary :

PDGFRA: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described. Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); Oncoprotein; Protein kinase, TK; Membrane protein, integral; TK group; PDGFR family. Chromosomal Location of Human Ortholog: 4q12. Cellular Component: microvillus; membrane; integral to plasma membrane; cytoplasm; plasma membrane; nucleus; intrinsic to plasma membrane; external side of plasma membrane. Molecular Function: vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; platelet-derived growth factor alpha-receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding. Biological Process: estrogen metabolic process; extracellular matrix organization and biogenesis; regulation of chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; nerve growth factor receptor signaling pathway; wound healing; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; palate development; elevation of cytosolic calcium ion concentration; positive regulation of fibroblast proliferation; Leydig cell differentiation; embryonic digestive tract morphogenesis; luteinization; positive regulation of cell proliferation; male genitalia development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; in utero embryonic development; adrenal gland development; positive regulation of phosphoinositide 3-kinase activity; embryonic cranial skeleton morphogenesis; odontogenesis of dentine-containing teeth; embryonic skeletal morphogenesis; positive regulation of phosphoinositide 3-kinase cascade; cell activation; innate immune response; hemopoietic progenitor cell differentiation; positive regulation of DNA replication; positive regulation of cell migration; lung development. Disease: Gastrointestinal Stromal Tumor; Hypereosinophilic Syndrome, Idiopathic

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590