Human MMP-24 (Matrix Metalloproteinase 24) ELISA Kit | MyBioSource MBS2509387 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human MMP-24 (Matrix Metalloproteinase 24) ELISA Kit

catalog :

MBS2509387

quantity :

96-Strip-Wells

price :

445 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2509387

products type :

ELISA Kit

products full name :

Human MMP-24 (Matrix Metalloproteinase 24) ELISA Kit

products short name :

MMP-24

other names :

matrix metalloproteinase-24 preproprotein; Matrix metalloproteinase-24; matrix metalloproteinase-24; matrix metalloproteinase 24 (membrane-inserted); membrane-type 5 matrix metalloproteinase; membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase; matrix metallopeptidase 24 (membrane-inserted); Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5; Membrane-type-5 matrix metalloproteinase; MT5-MMP; MT5MMP

products gene name :

MMP-24

other gene names :

MMP24; MMP24; MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5; MT5MMP; MMP-24; MT-MMP 5; MTMMP5; MT5-MMP; MT5MMP

uniprot entry name :

MMP24_HUMAN

reactivity :

Human

sequence length :

645

specificity :

This assay has high sensitivity and excellent specificity for detection of Human MMP-24. No significant cross-reactivity or interference between Human MMP-24 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human MMP-24 and all the analogues, therefore, cross reaction may still exist.

storage stability :

Store at 4 degree C.

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156--10ng/mL. Sensitivity: 0.094ng/mL

products description :

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of MMP-24 in human serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human MMP-24. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human MMP-24 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human MMP-24, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human MMP-24. You can calculate the concentration of Human MMP-24 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

5729929

ncbi acc num :

NP_006681.1

ncbi gb acc num :

NM_006690.3

uniprot acc num :

Q9Y5R2

ncbi mol weight :

73,231 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

uniprot summary :

MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family. Protein type: Activator; Membrane protein, integral; Protease; EC 3.4.24.-. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane. Molecular Function: zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding. Biological Process: positive regulation of catalytic activity; glial cell differentiation; detection of temperature stimulus involved in sensory perception of pain; proteolysis

size1 :

96-Strip-Wells

price1 :

445 USD

more info or order :

MyBioSource product webpage