Human FOXP1 (Forkhead Box Protein P1) ELISA Kit | MyBioSource MBS2508380 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human FOXP1 (Forkhead Box Protein P1) ELISA Kit

catalog :

MBS2508380

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2508380

products type :

ELISA Kit

products full name :

Human FOXP1 (Forkhead Box Protein P1) ELISA Kit

products short name :

[FOXP1]

other names :

[forkhead box protein P1 isoform 1; Forkhead box protein P1; forkhead box protein P1; fork head-related protein like B; glutamine-rich factor 1; mac-1-regulated forkhead; forkhead box P1; Mac-1-regulated forkhead]

products gene name :

[FOXP1]

other gene names :

[FOXP1; FOXP1; MFH; QRF1; 12CC4; hFKH1B; HSPC215]

uniprot entry name :

FOXP1_HUMAN

reactivity :

Human

sequence length :

677

specificity :

This kit recognizes natural and recombinant Human FOXP1. No significant cross-reactivity or interference between Human FOXP1 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Human FOXP1 concentrations in serum, plasma and other biological fluids. Principle of the Assay This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to FOXP1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for FOXP1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain FOXP1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of FOXP1. You can calculate the concentration of FOXP1 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

348605231

ncbi acc num :

NP_001231743.1

ncbi gb acc num :

NM_001244814.1

uniprot acc num :

Q9H334

ncbi mol weight :

77,249 Da

ncbi pathways :

MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

ncbi summary :

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing. Protein type: C2H2-type zinc finger protein; Cell cycle regulation; Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 3p14.1. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein binding; androgen receptor binding; sequence-specific DNA binding; metal ion binding. Biological Process: transcription from RNA polymerase II promoter; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; osteoclast differentiation; endothelial cell activation; regulation of transcription from RNA polymerase II promoter; regulation of monocyte differentiation; macrophage activation; monocyte activation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of tumor necrosis factor production; negative regulation of transcription, DNA-dependent; negative regulation of B cell apoptosis. Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590