Human TGF-beta3 (Transforming Growth Factor beta3) ELISA Kit | MyBioSource MBS2508221 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human TGF-beta3 (Transforming Growth Factor beta3) ELISA Kit

catalog :

MBS2508221

quantity :

48-Strip-Wells

price :

410 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2508221

products type :

ELISA Kit

products full name :

Human TGF-beta3 (Transforming Growth Factor beta3) ELISA Kit

products short name :

TGF-beta3

other names :

transforming growth factor beta-3 preproprotein; Transforming growth factor beta-3; transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3; transforming growth factor, beta 3

products gene name :

TGF-beta3

other gene names :

TGFB3; TGFB3; ARVD; RNHF; ARVD1; TGF-beta3; TGF-beta-3; LAP

uniprot entry name :

TGFB3_HUMAN

reactivity :

Human

sequence length :

412

specificity :

This assay has high sensitivity and excellent specificity for detection of Human TGF-beta3. No significant cross-reactivity or interference between Human TGF-beta3 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human TGF-beta3 and all the analogues, therefore, cross reaction may still exist.

storage stability :

Store at 4 degree C.

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 15.625--1000pg/mL. Sensitivity: 9.375pg/mL

products description :

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of TGF-beta3 in human serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human TGF-beta3. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human TGF-beta3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human TGF-beta3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human TGF-beta3. You can calculate the concentration of Human TGF-beta3 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

4507465

ncbi acc num :

NP_003230.1

ncbi gb acc num :

NM_003239.3

uniprot acc num :

P10600

ncbi mol weight :

35,708 Da

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83106)

ncbi summary :

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

uniprot summary :

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Protein type: Ligand, receptor tyrosine kinase; Cell development/differentiation; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 14q24. Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; extracellular region; plasma membrane; nucleus. Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity. Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; SMAD protein nuclear translocation; palate development; female pregnancy; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; uterine wall breakdown; positive regulation of filopodium formation; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; positive regulation of protein secretion; gut development; negative regulation of DNA replication; response to estrogen stimulus; positive regulation of cell division; regulation of MAPKKK cascade; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; blood coagulation; alveolus development; positive regulation of DNA replication. Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

size1 :

48-Strip-Wells

price1 :

410 USD

size2 :

96-Strip-Wells

price2 :

490

more info or order :

MyBioSource product webpage