Human TFR/CD71 (Transferrin Receptor) ELISA Kit | MyBioSource MBS2507578 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human TFR/CD71 (Transferrin Receptor) ELISA Kit

catalog :

MBS2507578

quantity :

48-Strip-Wells

price :

410 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2507578

products type :

ELISA Kit

products full name :

Human TFR/CD71 (Transferrin Receptor) ELISA Kit

products short name :

TFR/CD71

other names :

transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor (p90, CD71); transferrin receptor; T9; p90; CD_antigen: CD71Transferrin receptor protein 1, serum form; sTfR

products gene name :

TFR/CD71

other gene names :

TFRC; TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; TR; TfR; TfR1; Trfr; sTfR

uniprot entry name :

TFR1_HUMAN

reactivity :

Human

sequence length :

760

specificity :

This assay has high sensitivity and excellent specificity for detection of Human TFR/CD71. No significant cross-reactivity or interference between Human TFR/CD71 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human TFR/CD71 and all the analogues, therefore, cross reaction may still exist.

storage stability :

Store at 4 degree C.

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 1.563--100ng/mL. Sensitivity: 0.938ng/mL

products description :

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of TFR/CD71 in human serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human TFR/CD71. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human TFR/CD71 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human TFR/CD71, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human TFR/CD71. You can calculate the concentration of Human TFR/CD71 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

189458819

ncbi acc num :

NP_001121620.1

ncbi gb acc num :

NM_001128148.1

uniprot acc num :

P02786

ncbi mol weight :

84,871 Da

ncbi pathways :

Clathrin Derived Vesicle Budding Pathway (119545); Endocytosis Pathway (102279); Endocytosis Pathway (102181); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Golgi Associated Vesicle Biogenesis Pathway (119546); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Iron Metabolism In Placenta Pathway (672461)

ncbi summary :

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

uniprot summary :

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane. Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding. Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; regulation of cell growth; osteoclast differentiation; transmembrane transport; regulation of cell proliferation

size1 :

48-Strip-Wells

price1 :

410 USD

size2 :

96-Strip-Wells

price2 :

490

more info or order :

MyBioSource product webpage