ELISA/assay

Mouse GDF11(Growth Differentiation Factor 11)ELISA Kit

MBS2506362

48-Strip-Wells

410 USD

ELISA Kit

Mouse GDF11(Growth Differentiation Factor 11)ELISA Kit

GDF11

growth/differentiation factor 11; Growth/differentiation factor 11; growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11; growth differentiation factor 11; Bone morphogenetic protein 11; BMP-11

GDF11

GDF11; GDF11; BMP11; BMP-11; BMP11; GDF-11; BMP-11

GDF11_HUMAN

Mouse

407

This kit recognizes natural and recombinant Mouse GDF11. No significant cross-reactivity or interference between Mouse GDF11 and analogues was observed.

Store at 4 degree C.

Samples: Serum, plasma and other biological fluids. Assay Type: Sandwich. Detection Range: 15.625-1000pg/mL. Sensitivity: 9.375pg/mL

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Mouse GDF11 concentrations in serum, plasma and other biological fluids. Principle of the Assay This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to GDF11. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for GDF11 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain GDF11, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of GDF11. You can calculate the concentration of GDF11 in the samples by comparing the OD of the samples to the standard curve.

5031613

NP_005802.1

NM_005811.3

O95390

45,091 Da

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q13.2. Cellular Component: extracellular space. Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; skeletal development; cell development; metanephros development; growth

48-Strip-Wells

410 USD

96-Strip-Wells

490