Human CX3CR1 (Chemokine C-X3-C-Motif Receptor 1) ELISA Kit | MyBioSource MBS2505819 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human CX3CR1 (Chemokine C-X3-C-Motif Receptor 1) ELISA Kit

catalog :

MBS2505819

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2505819

products type :

ELISA Kit

products full name :

Human CX3CR1 (Chemokine C-X3-C-Motif Receptor 1) ELISA Kit

products short name :

[CX3CR1]

other names :

[CX3C chemokine receptor 1; CX3C chemokine receptor 1; CX3C chemokine receptor 1; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; G protein-coupled receptor 13; G-protein coupled receptor 13; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C) receptor 1; fractalkine receptor; chemokine (C-X3-C motif) receptor 1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28]

products gene name :

[CX3XR1]

other gene names :

[CX3CR1; CX3CR1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CMKBRL1; GPR13; C-X3-C CKR-1; CX3CR1; CMK-BRL1]

uniprot entry name :

CX3C1_HUMAN

reactivity :

Human

sequence length :

355

specificity :

This kit recognizes natural and some recombinant Human CX3CR1. No significant crossreactivity or interference between Human CX3CR1 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 15.625-1000pg/mL. Sensitivity: Min: 9.375pg/mL; Max: 1000pg/mL

products description :

Intended Uses: This ELISA kit can be applied to the in vitro quantitative determination of Human CX3CR1 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been precoated with an antibody specific to Human CX3CR1. Standards or samples are added to appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibodies specific for Human CX3CR1 and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Human CX3CR1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction will be terminated by adding Stop Solution and appears yellow in color. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Human CX3CR1. The concentration of Human CX3CR1 in samples can be calculated by comparing the OD of the samples with the standard curve.

ncbi gi num :

1351394

ncbi acc num :

P49238.1

uniprot acc num :

P49238

ncbi mol weight :

43,969 Da

ncbi summary :

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

uniprot summary :

CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Cell adhesion; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane. Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; cell adhesion; chemotaxis; macrophage chemotaxis; negative regulation of cell migration; microglial cell activation during immune response. Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590