Human CLDN3 (Claudin 3) ELISA Kit | MyBioSource MBS2505784 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human CLDN3 (Claudin 3) ELISA Kit

catalog :

MBS2505784

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2505784

products type :

ELISA Kit

products full name :

Human CLDN3 (Claudin 3) ELISA Kit

products short name :

[CLDN3]

other names :

[claudin-3; Claudin-3; claudin-3; CPE-R 2; CPE-receptor 2; Clostridium perfringens enterotoxin receptor 2; ventral prostate.1 protein homolog; ventral prostate.1-like protein; claudin 3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1]

products gene name :

[CLDN3]

other gene names :

[CLDN3; CLDN3; RVP1; HRVP1; C7orf1; CPE-R2; CPETR2; C7orf1; CPETR2; CPE-R 2; CPE-receptor 2; hRVP1]

uniprot entry name :

CLD3_HUMAN

reactivity :

Human

sequence length :

220

specificity :

This kit recognizes natural and some recombinant Human CLDN3. No significant crossreactivity or interference between Human CLDN3 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Intended Uses: This ELISA kit can be applied to the in vitro quantitative determination of Human CLDN3 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been precoated with an antibody specific to Human CLDN3. Standards or samples are added to appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibodies specific for Human CLDN3 and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Human CLDN3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction will be terminated by adding Stop Solution and appears yellow in color. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human CLDN3. The concentration of Human CLDN3 in samples can be calculated by comparing the OD of the samples with the standard curve.

ncbi gi num :

4502875

ncbi acc num :

NP_001297.1

ncbi gb acc num :

NM_001306.3

uniprot acc num :

O15551

ncbi mol weight :

23,319 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Tight Junction Pathway (83071)

ncbi summary :

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

uniprot summary :

Claudin-3: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cytoskeletal. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: tight junction; integral to plasma membrane; integral to membrane; lateral plasma membrane. Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity. Biological Process: response to hypoxia; signal transduction; calcium-independent cell-cell adhesion

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590