Porcine IL-1ra (Interleukin 1 Receptor Antagonist) ELISA Kit | MyBioSource MBS2505719 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Porcine IL-1ra (Interleukin 1 Receptor Antagonist) ELISA Kit

catalog :

MBS2505719

quantity :

24-Strip-Wells

price :

235 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2505719

products type :

ELISA Kit

products full name :

Porcine IL-1ra (Interleukin 1 Receptor Antagonist) ELISA Kit

products short name :

[IL-1ra]

other names :

[interleukin-1 receptor antagonist protein isoform 3; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist; interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor; INN: Anakinra]

products gene name :

[IL-1ra]

other gene names :

[IL1RN; IL1RN; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP]

uniprot entry name :

IL1RA_HUMAN

reactivity :

Porcine

sequence length :

159

specificity :

This kit recognizes natural and recombinantPorcineIL-1ra. No significant cross-reactivity or interference between PorcineIL-1ra and analogues was observed.

storage stability :

Store at 4 degree C.

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 62.5-4000pg/mL. Sensitivity: Min: 37.5pg/mL; Max: 4000pg/mL

other info2 :

Intra-assay Precision: Intra -assay Precision (Precision within an assay): 3 samples with low, middle and high level Porcine IL-1ra/IL-1F3 were tested 20times on one plate, respectively. Inter-assay Precision: Inter -assay Precision (Precision between assays): 3 samples with low, middle and high level Porcine IL-1ra/IL-1F3 were testedon 3 different plates, 20replicates in each plate.

products description :

Intended Uses: This ELISA kit applies to the invitro quantitative determination of PorcineIL-1raconcentrations in serum, plasma and other biological fluids.

ncbi gi num :

10835147

ncbi acc num :

NP_000568.1

ncbi gb acc num :

NM_000577.4

uniprot acc num :

P18510

ncbi mol weight :

16,142 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); IL-1 Signaling Pathway (198908); IL1-mediated Signaling Events Pathway (137944); Immune System Pathway (106386); Interleukin-1 Signaling Pathway (160141); Leptin Signaling Pathway (672456); SIDS Susceptibility Pathways (198901); Signaling By Interleukins Pathway (160140)

ncbi summary :

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Cytokine; Vesicle; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q14.2. Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular. Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity. Biological Process: response to drug; positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; fever; sensory perception of pain; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; immune response; response to activity; lipid metabolic process; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis. Disease: Gastric Cancer, Hereditary Diffuse; Microvascular Complications Of Diabetes, Susceptibility To, 4; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis

size1 :

24-Strip-Wells

price1 :

235 USD

size2 :

48-Strip-Wells

price2 :

450

size3 :

96-Strip-Wells

price3 :

535

size4 :

5x96-Strip-Wells

price4 :

2255

size5 :

10x96-Strip-Wells

price5 :

3975

more info or order :

MyBioSource product webpage