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Plasminogen Activator, Urokinase Receptor (uPAR)

MBS250546

0.01 mg

250 USD

MBS250546

Recombinant Protein

Plasminogen Activator, Urokinase Receptor (uPAR)

Plasminogen Activator, Urokinase Receptor (uPAR)

plasminogen activator; Tissue-type plasminogen activator; tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); plasminogen activator, tissue; INN: Alteplase; INN: ReteplaseCleaved into the following 2 chains:Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B

uPAR

PLAT; PLAT; TPA; T-PA; t-PA; t-plasminogen activator; tPA

TPA_HUMAN

E Coli

562

The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below. MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD WLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-GNSTHGCSSE ETFLlDCRGP MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV QYRSG

>95%

Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01 % sarcosyl.

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 Degree C for one month. Aliquot and store at -80 Degree C for 12 months. Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 Degree C for 48hrs, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-PAGE; WB; ELISA; IP. (May be suitable for use in other assays to be determined by the end user.)

Tag Information: two N-terminal Tags, His-tag and GST-tag. Residues: Gly221-Gly305 with two N-terminal Tags, His-tag and GST-tag. Accession #: Q03405. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor, Secreted. Predicted isoelectric point: 6.1. Predicted Molecular Mass: 41.1 kDa

Organism: Homo sapiens (Human). Endotoxin Level: Reconstitute in sterile PBS, pH7.2-pH7.4

339834

AAB59510.1

44,373 Da

Blood Clotting Cascade Pathway 198840!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Dissolution Of Fibrin Clot Pathway 106061!!Endochondral Ossification Pathway 198812!!Hemostasis Pathway 106028!!Selenium Pathway 198825!!Senescence And Autophagy Pathway 198780!!Signal Transduction Pathway 477114

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

0.01 mg

250 USD