catalog number :
MBS2504589
products type :
ELISA Kit
products full name :
Rat CREB (Cyclic AMP Response Element Binding Protein) ELISA Kit
products short name :
[CREB]
other names :
[CREB; Cyclic AMP-responsive element-binding protein 1; cyclic AMP-responsive element-binding protein 1; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; transactivator protein; cAMP responsive element binding protein 1]
products gene name :
[CREB]
other gene names :
[CREB1; CREB1; CREB; CREB-1; cAMP-responsive element-binding protein 1]
uniprot entry name :
CREB1_HUMAN
specificity :
This kit recognizes Rat CREB in samples. No Significant cross-reactivity or interference between Rat CREB and analogues was observed.
storage stability :
Store at 4 degree C.
image1 heading :
Typical Testing Data/Standard Curve (for reference only)
other info1 :
Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20pmol/mL. Sensitivity: Min: 0.188pmol/mL; Max: 20pmol/mL
other info2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat CREB were tested 20 times on one plate, respectively. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat CREB were tested on 3 different plates, 20 replicates in each plate.
products description :
Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Rat CREB concentrations in serum, plasma and other biological fluids.
ncbi acc num :
AAQ24858.1
ncbi mol weight :
25,445 Da
ncbi pathways :
AKT Phosphorylates Targets In The Nucleus Pathway (106476); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); ATF-2 Transcription Factor Network Pathway (138006); ATM Signaling Pathway (920969); Activated TLR4 Signalling Pathway (106400); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Adaptive Immune System Pathway (366160); Adipogenesis Pathway (198832); Adrenergic Signaling In Cardiomyocytes Pathway (908257)
ncbi summary :
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 2q34. Cellular Component: nucleoplasm; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; transcription cofactor activity; transcription factor activity. Biological Process: circadian rhythm; lactation; transcription from RNA polymerase II promoter; axon guidance; response to glucagon stimulus; nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; positive regulation of multicellular organism growth; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; response to organic substance; toll-like receptor 5 signaling pathway; synaptic transmission; toll-like receptor 4 signaling pathway; response to drug; epidermal growth factor receptor signaling pathway; mitochondrion organization and biogenesis; Notch signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; protein stabilization; secretory granule organization and biogenesis; organelle organization and biogenesis; MyD88-independent toll-like receptor signaling pathway; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; memory; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; phospholipase C activation; pituitary gland development; toll-like receptor signaling pathway; positive regulation of fat cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; regulation of cell size. Disease: Histiocytoma, Angiomatoid Fibrous
size5 :
10x96-Strip-Wells