Human CXCR3 (Chemokine CXC Receptor 3) ELISA Kit | MyBioSource MBS2504398 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human CXCR3 (Chemokine CXC Receptor 3) ELISA Kit

catalog :

MBS2504398

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2504398

products type :

ELISA Kit

products full name :

Human CXCR3 (Chemokine CXC Receptor 3) ELISA Kit

products short name :

[CXCR3]

other names :

[C-X-C chemokine receptor type 3 isoform 2; C-X-C chemokine receptor type 3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; G protein-coupled receptor 9; IP-10 receptor; IP10 receptor; Mig receptor; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor; chemokine (C-X-C motif) receptor 3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183]

products gene name :

[CXCR3]

other gene names :

[CXCR3; CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; GPR9; CXC-R3; CXCR-3; IP-10 receptor]

uniprot entry name :

CXCR3_HUMAN

reactivity :

Human

sequence length :

415

specificity :

This assay has high sensitivity and excellent specificity for detection of Human CXCR3. No significant cross-reactivity or interference between Human CXCR3 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human CXCR3 and all the analogues, therefore, cross reaction may still exist.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL

products description :

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CXCR3 in human serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human CXCR3. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human CXCR3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human CXCR3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human CXCR3. You can calculate the concentration of Human CXCR3 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

218563730

ncbi acc num :

NP_001136269.1

ncbi gb acc num :

NM_001142797.1

uniprot acc num :

P49682

ncbi mol weight :

28,715 Da

ncbi pathways :

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550)

ncbi summary :

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

uniprot summary :

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: Xq13. Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: C-X-C chemokine binding; chemokine receptor activity; chemokine binding; receptor activity; C-X-C chemokine receptor activity. Biological Process: apoptosis; positive regulation of chemotaxis; calcium-mediated signaling; positive regulation of cAMP metabolic process; chemotaxis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; negative regulation of angiogenesis; cell surface receptor linked signal transduction; negative regulation of endothelial cell proliferation; positive regulation of cell proliferation; regulation of leukocyte migration; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of release of sequestered calcium ion into cytosol; cell adhesion; inflammatory response; cell motility

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590