product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Rat IL-11 (Interleukin 11) ELISA Kit
catalog :
MBS2504083
quantity :
48-Strip-Wells
price :
410 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2504083
products type :
ELISA Kit
products full name :
Rat IL-11 (Interleukin 11) ELISA Kit
products short name :
IL-11
other names :
interleukin-11 isoform 1; Interleukin-11; interleukin-11; adipogenesis inhibitory factor; oprelvekin; interleukin 11; Adipogenesis inhibitory factor
products gene name :
IL-11
other gene names :
IL11; IL11; AGIF; IL-11; IL-11
uniprot entry name :
IL11_HUMAN
reactivity :
Rat
sequence length :
199
specificity :
This assay has high sensitivity and excellent specificity for detection of Rat IL-11. No significant cross-reactivity or interference between Rat IL-11 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat IL-11 and all the analogues, therefore, cross reaction may still exist.
storage stability :
Store at 4 degree C.
other info1 :
Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 15.625--1000pg/mL. Sensitivity: 9.375pg/mL
products description :
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of IL-11 in Rat serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-11. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Rat IL-11 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat IL-11, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Rat IL-11. You can calculate the concentration of Rat IL-11 in the samples by comparing the OD of the samples to the standard curve.
ncbi gi num :
10834994
ncbi acc num :
NP_000632.1
ncbi gb acc num :
NM_000641.3
uniprot acc num :
P20809
ncbi mol weight :
12,994 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Integrated Pancreatic Cancer Pathway (711360); Interleukin-11 Signaling Pathway (698753); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269)
ncbi summary :
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
uniprot summary :
IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily. Protein type: Cytokine; Secreted, signal peptide; Cell cycle regulation; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: growth factor activity; cytokine activity; interleukin-11 receptor binding. Biological Process: fat cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of MAPKKK cascade; megakaryocyte differentiation; B cell differentiation; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation
size1 :
48-Strip-Wells
price1 :
410 USD
size2 :
96-Strip-Wells
price2 :
490
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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