Mouse GDF6 (Growth Differentiation Factor 6) ELISA Kit | MyBioSource MBS2503539 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse GDF6 (Growth Differentiation Factor 6) ELISA Kit

catalog :

MBS2503539

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2503539

products type :

ELISA Kit

products full name :

Mouse GDF6 (Growth Differentiation Factor 6) ELISA Kit

products short name :

[GDF6]

other names :

[growth/differentiation factor 6; Growth/differentiation factor 6; growth/differentiation factor 6; GDF-6; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome; bone morphogenetic protein 13; growth/differentiation factor 16; growth differentiation factor 6; Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16]

products gene name :

[GDF6]

other gene names :

[GDF6; GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6; BMP13; GDF16; GDF-6; BMP-13]

uniprot entry name :

GDF6_HUMAN

reactivity :

Mouse

sequence length :

455

specificity :

This kit recognizes natural and recombinant Mouse GDF6. No significant cross-reactivity or interference between Mouse GDF6 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Mouse GDF6 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to GDF6. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for GDF6 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain GDF6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of GDF6. You can calculate the concentration of GDF6 in the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

48475062

ncbi acc num :

NP_001001557.1

ncbi gb acc num :

NM_001001557.2

uniprot acc num :

Q6KF10

ncbi mol weight :

50,662 Da

ncbi pathways :

Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]

uniprot summary :

GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family. Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell development/differentiation. Chromosomal Location of Human Ortholog: 8q22.1. Cellular Component: extracellular space. Molecular Function: protein homodimerization activity; growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: regulation of apoptosis; BMP signaling pathway; apoptosis; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; activin receptor signaling pathway; positive regulation of neuron differentiation; cell development; growth. Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Microphthalmia, Isolated 4; Leber Congenital Amaurosis 17; Microphthalmia, Isolated, With Coloboma 6

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590