Human MMP-17 (Matrix Metalloproteinase 17) ELISA Kit | MyBioSource MBS2502744 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human MMP-17 (Matrix Metalloproteinase 17) ELISA Kit

catalog :

MBS2502744

quantity :

24-Strip-Wells

price :

190 USD

product information

catalog number :

MBS2502744

products type :

ELISA Kit

products full name :

Human MMP-17 (Matrix Metalloproteinase 17) ELISA Kit

products short name :

[MMP-17]

other names :

[matrix metalloproteinase-17 preproprotein; Matrix metalloproteinase-17; matrix metalloproteinase-17; MMP-17; MT-MMP 4; MT4MMP; MTMMP4; matrix metalloproteinase 17 (membrane-inserted); membrane-type matrix metalloproteinase 4; membrane-type-4 matrix metalloproteinase; matrix metallopeptidase 17 (membrane-inserted); Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP]

products gene name :

[MMP-17]

other gene names :

[MMP17; MMP17; MT4-MMP; MT4MMP; MMP-17; MT-MMP 4; MTMMP4; MT4-MMP; MT4MMP]

uniprot entry name :

MMP17_HUMAN

reactivity :

Human

sequence length :

603

specificity :

This kit recognizes natural and some recombinant Human MMP-17. No significant crossreactivity or interference between Human MMP-17 and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.156-10ng/mL. Sensitivity: Min: 0.094ng/mL; Max: 10ng/mL

products description :

Intended Uses: This ELISA kit can be applied to the in vitro quantitative determination of Human MMP-17 concentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been precoated with an antibody specific to Human MMP-17. Standards or samples are added to appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibodies specific for Human MMP-17 and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Human MMP-17, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction will be terminated by adding Stop Solution and appears yellow in color. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human MMP-17. The concentration of Human MMP-17 in samples can be calculated by comparing the OD of the samples with the standard curve.

ncbi gi num :

112382270

ncbi acc num :

NP_057239.4

ncbi gb acc num :

NM_016155.4

uniprot acc num :

Q9ULZ9

ncbi mol weight :

57,938 Da

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900)

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]

uniprot summary :

MMP17: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor; Activator; EC 3.4.24.-; Membrane protein, integral; Protease. Chromosomal Location of Human Ortholog: 12q24.3. Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane. Molecular Function: zinc ion binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding. Biological Process: positive regulation of catalytic activity; proteolysis

size1 :

24-Strip-Wells

price1 :

190 USD

size2 :

48-Strip-Wells

price2 :

310

size3 :

96-Strip-Wells

price3 :

355

size4 :

5x96-Strip-Wells

price4 :

1435

size5 :

10x96-Strip-Wells

price5 :

2805