Human BGN (Biglycan) ELISA Kit | MyBioSource MBS2500659 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human BGN (Biglycan) ELISA Kit

catalog :

MBS2500659

quantity :

24-Strip-Wells

price :

215 USD

product information

catalog number :

MBS2500659

products type :

ELISA Kit

products full name :

Human BGN (Biglycan) ELISA Kit

products short name :

[BGN]

other names :

[biglycan preproprotein; Biglycan; biglycan; biglycan proteoglycan; bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; small leucine-rich protein 1A; biglycan; Bone/cartilage proteoglycan I; PG-S1]

products gene name :

[BGN]

other gene names :

[BGN; BGN; PGI; DSPG1; PG-S1; SLRR1A; SLRR1A]

uniprot entry name :

PGS1_HUMAN

reactivity :

Human

sequence length :

368

specificity :

This kit recognizes natural and recombinantHumanBGN. No significant cross-reactivity or interference between HumanBGN and analogues was observed.

storage stability :

Store at 4 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 0.313-20ng/mL. Sensitivity: Min: 0.188ng/mL; Max: 20ng/mL

products description :

Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanBGNconcentrations in serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to BGN. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for BGNand Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain BGN, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of BGN.You can calculate the concentration of BGNin the samples by comparing the OD of the samples to the standard curve.

ncbi gi num :

4502403

ncbi acc num :

NP_001702.1

ncbi gb acc num :

NM_001711.4

uniprot acc num :

P21810

ncbi mol weight :

41,654 Da

ncbi pathways :

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway (645305); CS/DS Degradation Pathway (645311); Chondroitin Sulfate Biosynthesis Pathway (645309); Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway (645308); Defective B3GAT3 Causes JDSSDHD Pathway (1127588); Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway (1127592); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1127587); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1127591); Defective CHST3 Causes SEDCJD Pathway (1127590); Defective CHST6 Causes MCDC1 Pathway (1127593)

ncbi summary :

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]

uniprot summary :

BGN: May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; transport vesicle; cell surface; Golgi lumen; extracellular region; sarcolemma. Molecular Function: glycosaminoglycan binding; extracellular matrix binding; extracellular matrix structural constituent. Biological Process: chondroitin sulfate metabolic process; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; blood vessel remodeling; pathogenesis; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; dermatan sulfate biosynthetic process

size1 :

24-Strip-Wells

price1 :

215 USD

size2 :

48-Strip-Wells

price2 :

410

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2040

size5 :

10x96-Strip-Wells

price5 :

3590