ELISA/assay

Mouse I-TAC (Interferon Inducible T-Cell Alpha Chemoattractant) ELISA Kit

MBS2500500

48-Strip-Wells

410 USD

ELISA Kit

Mouse I-TAC (Interferon Inducible T-Cell Alpha Chemoattractant) ELISA Kit

I-TAC

I-TAC, partial; C-X-C motif chemokine 11; C-X-C motif chemokine 11; beta-R1; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; small-inducible cytokine B11; chemokine (C-X-C motif) ligand 11; Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11

I-TAC

CXCL11; CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B; ITAC; SCYB11; SCYB9B; IP-9; I-TAC

CXL11_HUMAN

Mouse

73

This assay has high sensitivity and excellent specificity for detection of Mouse I-TAC. No significant cross-reactivity or interference between Mouse I-TAC and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse I-TAC and all the analogues, therefore, cross reaction may still exist.

Store at 4 degree C.

Samples: Serum, Plasma, Biological Fluids. Assay Type: Sandwich. Detection Range: 62.5--4000pg/mL. Sensitivity: 37.5pg/mL

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of I-TAC in Mouse serum, plasma and other biological fluids. Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse I-TAC. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse I-TAC and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse I-TAC, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse I-TAC. You can calculate the concentration of Mouse I-TAC in the samples by comparing the OD of the samples to the standard curve.

14030443

AAK52900.1

O14625

10,365 Da

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550)

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Chemokine. Chromosomal Location of Human Ortholog: 4q21.2. Cellular Component: extracellular space; extracellular region. Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity. Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; inflammatory response; chemotaxis; signal transduction; regulation of cell proliferation

48-Strip-Wells

410 USD

96-Strip-Wells

490