catalog number :
MBS248934
products full name :
Rabbit Polyclonal (IgG) to Human PIBF1 / PIBF
products short name :
[PIBF1 / PIBF]
products name syn :
[PIBF1 Antibody: PIBF, CEP90, C13orf24, PIBF, Progesterone-induced-blocking factor 1]
other names :
[progesterone-induced-blocking factor 1; Progesterone-induced-blocking factor 1; progesterone-induced-blocking factor 1; progesterone-induced blocking factor 1; progesterone immunomodulatory binding factor 1]
products gene name :
[PIBF1]
products gene name syn :
[PIBF]
other gene names :
[PIBF1; PIBF1; PIBF; CEP90; C13orf24; C13orf24; PIBF]
uniprot entry name :
PIBF1_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Multiple isoforms of PIBF1 exists as a result of alternative splicing event.
purity :
PIBF1 Antibody is affinity chromatography purified via peptide column
form :
Liquid; PIBF1 Antibody is supplied in PBS containing 0.02% sodium azide
storage stability :
PIBF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
tested application :
ELISA (EIA), Immunofluorescence (IF), Immunoistochemistry -Paraffin (IHC-P), Western Blot (WB).
app notes :
IHC-Paraffin (10 ug/mL). Immunofluorescence (20 ug/mL). Western Blot (1-2 ug/mL). Optimal dilution to be determined by the researcher.
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunofluorescence (IF)
image3 heading :
Western Blot (WB)
other info1 :
Immunogen: Rabbit polyclonal PIBF1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human PIBF1. The immunogen is located within amino acids 610 - 660 of PIBF1. Purification: PIBF1 Antibody is affinity chromatography purified via peptide column. Conjugate: Unconjugated. Positive Control: MBS151766 - Human Placenta Tissue Lysate. MBS154333 - Human Spleen Tissue Slide
products description :
PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.
ncbi acc num :
NP_006337.2
ncbi gb acc num :
NM_006346.2
ncbi mol weight :
Predicted: 83 kDa
uniprot summary :
PIBF1: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect. 3 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 13q22.1. Cellular Component: centrosome. Molecular Function: protein binding