product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Polyclonal (IgG) to Human GPBAR1 / TGR5
catalog :
MBS248699
quantity :
0.05 mL
price :
530 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Anti-GPBAR1 / TGR5 antibody IHC staining of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
product information
catalog number :
MBS248699
products type :
Antibody
products full name :
Rabbit Polyclonal (IgG) to Human GPBAR1 / TGR5
products short name :
[GPBAR1 / TGR5]
products name syn :
[Anti-GPBAR1 / TGR5 Antibody (Internal) IHC-plus; GPBAR1; BG37; GPR131; HGPCR19; M-BAR; GPCR19; TGR5; GPCR TGR5; HBG37; Membrane bile acid receptor; Human GPBAR1; TGR5]
other names :
[G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor 1; hBG37; hGPCR19; membrane bile acid receptor; G-protein coupled receptor GPCR19; membrane-type receptor for bile acids; G-protein coupled bile acid receptor BG37; G protein-coupled bile acid receptor 1; G-protein coupled receptor GPCR19; hGPCR19; Membrane-type receptor for bile acids; M-BAR; hBG37; BG37]
products gene name :
[GPBAR1]
products gene name syn :
[TGR5]
other gene names :
[GPBAR1; GPBAR1; BG37; TGR5; M-BAR; GPCR19; GPR131; TGR5; hGPCR19; M-BAR; BG37]
uniprot entry name :
GPBAR_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
330
specificity :
Human TGR5
purity :
Immunoaffinity Purified
form :
PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
concentration :
1 mg/ml
storage stability :
Upon Arrival: Aliquot and freeze at -20 degree C. Avoid freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
app notes :
ELISA, IHC-P (10 ug/ml). Usage: Antibody reactive against peptide, detects immunogen.
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Target: GPBAR1/TGR5. Target Species: Human. Immunogen Description: Synthetic peptide corresponding to a region within amino acids 157 and 252 of TGR5 (SwissProt Q8TDU6). Percent identity by BLAST analysis: Human (100%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: GPBAR1 / TGR5 antibody was raised against synthetic peptide corresponding to a region within amino acids 157 and 252 of TGR5 (SwissProt Q8TDU6). Percent identity by BLAST analysis: Human (100%). Antigen Modification: Internal. Immunogen Species: GPBAR1/TGR5 antibody was raised against Human. Antigen Type: Synthetic peptide
products categories :
Family: GPCR. Subfamily: Bile Acids
products description :
BG37/TGR5 is the first Bile Acid GPCR to be identified.
ncbi gi num :
24850109
ncbi acc num :
NP_733800.1
ncbi gb acc num :
NM_170699.2
uniprot acc num :
Q8TDU6
ncbi mol weight :
35,248 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)
ncbi summary :
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
uniprot summary :
GPBAR1: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 2q35. Cellular Component: cytoplasm; integral to membrane; plasma membrane. Biological Process: G-protein coupled receptor protein signaling pathway
size1 :
0.05 mL
price1 :
530 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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