catalog number :
MBS247973
products full name :
Rabbit Polyclonal to Human WNT6
products short name :
WNT6
products name syn :
Anti-WNT6 Antibody (N-Terminus) IHC-plus; WNT6; Protein Wnt-6; Human WNT6
other names :
protein Wnt-6; Protein Wnt-6; protein Wnt-6; wingless-type MMTV integration site family, member 6
products gene name :
WNT6
other gene names :
WNT6; WNT6
uniprot entry name :
WNT6_HUMAN
reactivity :
Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Mouse, Rabbit, Rat. Predicted Reactivity: Monkey, Bat (at least 90% immunogen sequence identity)
specificity :
Human WNT6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
purity :
Immunoaffinity Purified
form :
PBS, 0.1% sodium azide.
storage stability :
Long term: -70 degree C; Short term: +4 degree C
tested application :
Immunohistochemistry (IHC - Paraffin)
app notes :
IHC-P (15 ug/ml)
other info1 :
Target Species: Human. Immunogen Description: Synthetic 20 amino acid peptide from N-terminus of human WNT6. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse, Rabbit (100%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: WNT6 antibody was raised against synthetic 20 amino acid peptide from N-terminus of human WNT6. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse, Rabbit (100%); Marmoset, Bat, Opossum, Platypus (95%). Antigen Modification: N-Terminus
products categories :
Family: WNT
products description :
Wnt genes encode a family of secreted proteins having oncogenic potential and important roles in developmental processes. In developing mice, Wnt 6 is expressed panectodermally and in the somites, limb bud and reproductive system. The WNT6 signaling pathway has been suggested to affect human breast cancer, colon cancer, and leukemia.
ncbi acc num :
NP_006513.1
ncbi gb acc num :
NM_006522.3
ncbi mol weight :
39,721 Da
ncbi pathways :
Basal Cell Carcinoma Pathway 83113!!Basal Cell Carcinoma Pathway 525!!Class B/2 (Secretin Family Receptors) Pathway 106378!!DNA Damage Response (only ATM Dependent) Pathway 198827!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!GPCR Ligand Binding Pathway 161020!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!Hedgehog Signaling Pathway 83063
ncbi summary :
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]