Chicken Polyclonal (IgY) to Human TUBB3 / Tubulin Beta 3 | MyBioSource MBS247962 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Chicken Polyclonal (IgY) to Human TUBB3 / Tubulin Beta 3

catalog :

MBS247962

quantity :

0.05 mL

price :

530 USD

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-Tuj1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

product information

catalog number :

MBS247962

products type :

Antibody

products full name :

Chicken Polyclonal (IgY) to Human TUBB3 / Tubulin Beta 3

products short name :

[TUBB3 / Tubulin Beta 3]

products name syn :

[Anti-TUBB3 / Tubulin Beta 3 Antibody IHC-plus; TUBB3; CDCBM; Beta III Tubulin; Class III beta-tubulin; TUBB4; Tubulin; beta 3; Tubulin beta-III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin; beta 3 class III; CFEOM3A; Human TUBB3; Tubulin Beta 3]

other names :

[tubulin beta-3 chain isoform 1; Tubulin beta-3 chain; tubulin beta-3 chain; tubulin beta-III; tubulin beta-4 chain; class III beta-tubulin; tubulin, beta 3 class III; Tubulin beta-4 chain; Tubulin beta-III]

products gene name :

[TUBB3]

other gene names :

[TUBB3; TUBB3; CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A; TUBB4]

uniprot entry name :

TBB3_HUMAN

clonality :

Polyclonal

isotype :

IgY

host :

Chicken

reactivity :

Human, Mouse, Rat

sequence length :

450

specificity :

Recognizes human Tuj 1.

purity :

Immunoaffinity Purified

form :

PBS, pH 7.2, 0.02% sodium azide

concentration :

0.3 mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)

app notes :

ICC (1:100 - 1:200), IHC-P (5 ug/ml), WB (1:250 - 1:500). Usage: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Western Blot: 1:250-1:500. Immunohistochemistry: 1:100-1:200. Immunocytochemistry: 1:100-1:200.

image1 heading :

Immunohistochemistry (IHC)

other info1 :

Target Species: Human. Immunogen Description: Peptide corresponded to a region of the Tuj 1 gene product shared between the rat (AAM28438, NCBI) and human (AAL28094, NCBI) gene products.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: TUBB3 / Tubulin Beta 3 antibody was raised against peptide corresponded to a region of the Tuj 1 gene product shared between the rat (AAM28438, NCBI) and human (AAL28094, NCBI) gene products.

products categories :

Family: Tubulin

ncbi gi num :

50592996

ncbi acc num :

NP_006077.2

ncbi gb acc num :

NM_006086.3

uniprot acc num :

Q13509

ncbi mol weight :

42,433 Da

ncbi pathways :

Chaperonin-mediated Protein Folding Pathway (106242); Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway (106243); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway (106245); Gap Junction Pathway (83072); Gap Junction Pathway (483); Metabolism Of Proteins Pathway (106230); Orphan Transporters Pathway (1127546); Parkin-Ubiquitin Proteasomal System Pathway (700638); Pathogenic Escherichia Coli Infection Pathway (83103)

ncbi summary :

This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]

uniprot summary :

TUBB3: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16q24.3. Cellular Component: microtubule; cell soma; axon; cytoplasm; dendrite; nucleus. Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; peptide binding. Biological Process: protein polymerization; axon guidance; de novo posttranslational protein folding; mitosis; cellular protein metabolic process; protein folding; transmembrane transport; microtubule-based process. Disease: Fibrosis Of Extraocular Muscles, Congenital, 3a, With Or Without Extraocular Involvement; Cortical Dysplasia, Complex, With Other Brain Malformations 1

size1 :

0.05 mL

price1 :

530 USD

more info or order :

MyBioSource product webpage